Emergence of New Delhi metallo-β-lactamase type 1-producing Enterobacteriaceae and non-Enterobacteriaceae: global case detection and bacterial surveillance
Emergence of New Delhi metallo-β-lactamase type 1-producing Enterobacteriaceae and non-Enterobacteriaceae: global case detection and bacterial surveillance
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DOI：
10.1016/j.ijid.2012.11.025
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发表时间：
2013-05-01
影响因子：
8.4
通讯作者：
Mundy, Linda M.
中科院分区：
文献类型：
--
作者：
Bushnell, Greta;Mitrani-Gold, Fanny;Mundy, Linda M.
目的：对2008年1月至2011年7月6日全球范围内报告的产新德里1型金属β-内酰胺酶（NDM-1）细菌的人间病例和监测报告进行描述性和分子流行病学分析。研究分为两大类（1）病例系列和病例报告的NDM-1产生的细菌，或（2）主动监测和环境监测研究的NDM-1产生的bacteries.Results：60例NDM-1产生的细菌报告在3.5年的间隔，因为索引病例检测。大多数报告的病例为无感染证据的定植（n = 39，65%）;尿液是感染（41.7%）和定植（33.3%）病例的最常见标本来源。17例（28.3%）在多个身体部位有NDM-1产生菌。肺炎克雷伯氏菌和大肠埃希氏菌是检出率最高的两种细菌，34株大肠埃希氏菌的多位点序列类型数据显示，埃希菌和肺炎临床分离株提供了产NDM-1细菌的不完整但不均匀的全球分布。大多数情况（63.3%）暴露于南亚中南亚的印度次大陆，实验室监测系统以及印度的环境调查表明，存在潜在的人类感染和NDM-1产生细菌定植的环境水库。大多数NDM-1产生细菌的病例报告假定为一种或多种细菌的定植，而不是感染。现有的人类病例报告和监测数据表明，产NDM-1的肠杆菌科和非肠杆菌科在全球范围内分布。(C)2012年国际传染病学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: A systematic review of the literature was conducted to summarize the descriptive and molecular epidemiology of human cases and surveillance reports with New Delhi metallo-beta-lactamase type 1 (NDM-1)-producing bacteria reported worldwide from January 2008 through July 6, 2011.Methods: A comprehensive literature review was conducted to identify publications of NDM-1-producing bacteria. Studies were divided into two broad categories of (1) case series and case reports of NDM-1-producing bacteria, or (2) active surveillance and environmental surveillance studies of NDM-1-producing bacteria.Results: Sixty cases with NDM-1-producing bacteria were reported in the 3.5-year interval since the index case detection. The majority of reported cases represented colonization without evidence of infection (n = 39, 65%); urine was the most common specimen source for cases with infection (41.7%) and colonization (33.3%). Seventeen cases (28.3%) had NDM-1-producing bacteria at more than one body site. Klebsiella pneumoniae and Escherichia coli were the most frequent bacteria detected, and the multilocus sequence type data from 34 E. coli and K. pneumoniae clinical isolates provided an incomplete, yet heterogeneous global distribution of NDM-1-producing bacteria. The majority of cases (63.3%) had exposure to the Indian subcontinent of south central Asia, and laboratory surveillance systems, as well as an environmental survey from India, suggest a presence of environmental reservoirs for potential human infection and colonization with NDM-1-producing bacteria.Conclusions: The majority of case reports with NDM-1-producing bacteria had presumed colonization, not infection, with one or more bacteria. The available human case reports and surveillance data suggest a global distribution of NDM-1-producing Enterobacteriaceae and non-Enterobacteriaceae. (C) 2012 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.