Further characterization of the human inducer T cell subset defined by monoclonal antibody.
Further characterization of the human inducer T cell subset defined by monoclonal antibody.
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由单克隆抗体定义的人类诱导 T 细胞亚群的进一步表征。
DOI：
10.4049/jimmunol.123.6.2894
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发表时间：
1979
影响因子：
4.4
通讯作者：
S. Schlossman
中科院分区：
文献类型：
--
作者：
E. Reinherz;P. Kung;G. Goldstein;S. Schlossman
有证据表明，OKTA+ T细胞亚群的人，定义的单克隆杂交瘤抗体，提供了帮助B淋巴细胞分化的PWM驱动系统。B细胞增殖和胞浆内免疫球蛋白合成均由OKT 4+而非OKT 4- T细胞促进。鉴于早期的研究表明OKT 4 + T细胞是产生细胞毒性T细胞所必需的，而本研究表明OKT+ T细胞是B细胞分化所必需的，看来OKT+群体是主要的人T辅助（诱导）亚群。
Evidence is presented that the OKTA+ T cell subset in man, defined by a monoclonal hybridoma antibody, provides help for B lymphocyte differentiation in a PWM driven system. Both B cell proliferation and intracytoplasmic immunoglobulin synthesis are facilitated by OKT4+ and not by OKT4- T cells. Given earlier studies demonstrating that OKT4+ T cells were necessary for generation of T cytotoxic cells and the present study that OKT+ T cells are necessary for the differentiation of B cells, it would appear that the OKT+ population is the major human T helper (inducer) subset.