Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer.
Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer.
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晚期非小细胞肺癌中循环肿瘤DNA引导的疗法的总生存期。
DOI：
10.1038/s41591-022-02047-z
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发表时间：
2022-11
期刊：
影响因子：
82.9
通讯作者：
Li, Bob T.
中科院分区：
文献类型：
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作者：
Jee, Justin;Lebow, Emily S.;Yeh, Randy;Das, Jeeban P.;Namakydoust, Azadeh;Paik, Paul K.;Chaft, Jamie E.;Jayakumaran, Gowtham;Brannon, A. Rose;Benayed, Ryma;Zehir, Ahmet;Donoghue, Mark;Schultz, Nikolaus;Chakravarty, Debyani;Kundra, Ritika;Madupuri, Ramyasree;Murciano-Goroff, Yonina R.;Tu, Hai-Yan;Xu, Chong-Rui;Martinez, Andres;Wilhelm, Clare;Galle, Jesse;Daly, Bobby;Yu, Helena A.;Offin, Michael;Hellmann, Matthew D.;Lito, Piro;Arbour, Kathryn C.;Zauderer, Marjorie G.;Kris, Mark G.;Ng, Kenneth K.;Eng, Juliana;Preeshagul, Isabel;Lai, W. Victoria;Fiore, John J.;Iqbal, Afsheen;Molena, Daniela;Rocco, Gaetano;Park, Bernard J.;Lim, Lee P.;Li, Mark;Tong-Li, Candace;De Silva, Madhawa;Chan, David L.;Diakos, Connie, I;Itchins, Malinda;Clarke, Stephen;Pavlakis, Nick;Lee, Adrian;Rekhtman, Natasha;Chang, Jason;Travis, William D.;Riely, Gregory J.;Solit, David B.;Gonen, Mithat;Rusch, Valerie W.;Rimner, Andreas;Gomez, Daniel;Drilon, Alexander;Scher, Howard, I;Shah, Sohrab P.;Berger, Michael F.;Arcila, Maria E.;Ladanyi, Marc;Levine, Ross L.;Shen, Ronglai;Razavi, Pedram;Reis-Filho, Jorge S.;Jones, David R.;Rudin, Charles M.;Isbell, James M.;Li, Bob T.
循环肿瘤DNA（ctDNA）测序指导治疗决策，但主要在小队列中进行研究，没有足够的随访来确定其对总生存期的影响。我们前瞻性地随访了1,127例接受ctDNA指导治疗的非小细胞肺癌患者的国际队列。ctDNA检测与较短的生存期相关（风险比（HR），2.05; 95%置信区间（CI），1.74-2.42; P < 0.001），与临床病理特征和代谢肿瘤体积无关。在722例（64%）可检测到ctDNA的患者中，255例（23%）通过ctDNA测序匹配靶向治疗的患者的生存期长于未接受靶向治疗的患者（HR，0.63; 95%CI，0.52-0.76; P < 0.001）。在25%的患者中发现了时间匹配组织测序未检测到的ctDNA基因组改变。这些仅ctDNA的改变不成比例地具有耐药性的亚克隆驱动因素，包括RICTOR和PIK 3CA改变，并且与短生存期相关。微创ctDNA分析可以识别组织测序中未捕获的异质驱动因素，并扩大社区获得延长生命治疗的机会。
Circulating tumor DNA (ctDNA) sequencing guides therapy decisions but has been studied mostly in small cohorts without sufficient follow-up to determine its influence on overall survival. We prospectively followed an international cohort of 1,127 patients with non-small-cell lung cancer and ctDNA-guided therapy. ctDNA detection was associated with shorter survival (hazard ratio (HR), 2.05; 95% confidence interval (CI), 1.74–2.42; P < 0.001) independently of clinicopathologic features and metabolic tumor volume. Among the 722 (64%) patients with detectable ctDNA, 255 (23%) matched to targeted therapy by ctDNA sequencing had longer survival than those not treated with targeted therapy (HR, 0.63; 95% CI, 0.52–0.76; P < 0.001). Genomic alterations in ctDNA not detected by time-matched tissue sequencing were found in 25% of the patients. These ctDNA-only alterations disproportionately featured subclonal drivers of resistance, including RICTOR and PIK3CA alterations, and were associated with short survival. Minimally invasive ctDNA profiling can identify heterogeneous drivers not captured in tissue sequencing and expand community access to life-prolonging therapy.
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影响因子：
16.6
作者：
Chabon JJ;Simmons AD;Lovejoy AF;Esfahani MS;Newman AM;Haringsma HJ;Kurtz DM;Stehr H;Scherer F;Karlovich CA;Harding TC;Durkin KA;Otterson GA;Purcell WT;Camidge DR;Goldman JW;Sequist LV;Piotrowska Z;Wakelee HA;Neal JW;Alizadeh AA;Diehn M
通讯作者：
Diehn M
DOI：
10.1016/j.jtho.2018.03.035
发表时间：
2018-08
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Lisberg A;Cummings A;Goldman JW;Bornazyan K;Reese N;Wang T;Coluzzi P;Ledezma B;Mendenhall M;Hunt J;Wolf B;Jones B;Madrigal J;Horton J;Spiegel M;Carroll J;Gukasyan J;Williams T;Sauer L;Wells C;Hardy A;Linares P;Lim C;Ma L;Adame C;Garon EB
通讯作者：
Garon EB
影响因子：
64.8
作者：
Karczewski, Konrad J;Francioli, Laurent C;MacArthur, Daniel G
通讯作者：
MacArthur, Daniel G
影响因子：
28.4
作者：
Aggarwal, Charu;Thompson, Jeffrey C.;Carpenter, Erica L.
通讯作者：
Carpenter, Erica L.
影响因子：
120.7
作者：
Kris, Mark G.;Johnson, Bruce E.;Berry, Lynne D.;Kwiatkowski, David J.;Iafrate, A. John;Wistuba, Ignacio I.;Varella-Garcia, Marileila;Franklin, Wilbur A.;Aronson, Samuel L.;Su, Pei-Fang;Shyr, Yu;Camidge, D. Ross;Sequist, Lecia V.;Glisson, Bonnie S.;Khuri, Fadlo R.;Garon, Edward B.;Pao, William;Rudin, Charles;Schiller, Joan;Haura, Eric B.;Socinski, Mark;Shirai, Keisuke;Chen, Heidi;Giaccone, Giuseppe;Ladanyi, Marc;Kugler, Kelly;Minna, John D.;Bunn, Paul A.
通讯作者：
Bunn, Paul A.