Genomic Epidemiology of SARS-CoV-2 in Western Burkina Faso, West Africa.

Genomic Epidemiology of SARS-CoV-2 in Western Burkina Faso, West Africa.
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DOI:
10.3390/v14122788
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发表时间:
2022-12-14
期刊:
Viruses
影响因子:
--
通讯作者:
Ouedraogo AS
Ouedraogo AS
中科院分区:
其他
文献类型:
--
作者:
Sawadogo Y;Galal L;Belarbi E;Zongo A;Schubert G;Leendertz F;Kanteh A;Sesay AK;Erhart A;Bañuls AL;Tarnagda Z;Godreuil S;Tinto H;Ouedraogo AS

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背景:中国,自2019年12月在武汉首次发现后,SARS-CoV-2迅速传播,在全球范围内引发接连的疫情浪潮。本研究旨在提供布基纳法索SARS-CoV-2的基因组流行病学。方法:对2022年5月5日至2022年1月31日收集的377份聚合酶链式反应阳性的鼻咽标本(聚合酶链式反应周期阈值评分35分)进行分析。使用NextClade将基因组序列分配给系统发育支系,使用穿山甲将基因组序列分配给穿山甲谱系。进行了系统发育和系统地理分析,以确定布基纳法索病毒传入的地理来源和时间。结果:所分析的SARS-CoV-2基因组可归属于世界上已描述的10个系统发育分支和27个Pango谱系。我们的分析揭示了跨境人员流动在布基纳法索从邻国相继传入SARS-CoV-2中的重要作用。结论:这项研究为了解西非SARS-CoV-2的基因组流行病学提供了更多的见解。它强调了陆路旅行在病毒传播中的重要性,以及迅速实施预防政策的必要性。区域跨界合作和普通民众对政府政策的坚持是防止新的疫情浪潮的关键。
Background: After its initial detection in Wuhan, China, in December 2019, SARS-CoV-2 has spread rapidly, causing successive epidemic waves worldwide. This study aims to provide a genomic epidemiology of SARS-CoV-2 in Burkina Faso. Methods: Three hundred and seventy-seven SARS-CoV-2 genomes obtained from PCR-positive nasopharyngeal samples (PCR cycle threshold score < 35) collected between 5 May 2020, and 31 January 2022 were analyzed. Genomic sequences were assigned to phylogenetic clades using NextClade and to Pango lineages using pangolin. Phylogenetic and phylogeographic analyses were performed to determine the geographical sources and time of virus introduction in Burkina Faso. Results: The analyzed SARS-CoV-2 genomes can be assigned to 10 phylogenetic clades and 27 Pango lineages already described worldwide. Our analyses revealed the important role of cross-border human mobility in the successive SARS-CoV-2 introductions in Burkina Faso from neighboring countries. Conclusions: This study provides additional insights into the genomic epidemiology of SARS-CoV-2 in West Africa. It highlights the importance of land travel in the spread of the virus and the need to rapidly implement preventive policies. Regional cross-border collaborations and the adherence of the general population to government policies are key to prevent new epidemic waves.
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期刊: Science (New York, N.Y.)
影响因子: --
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