White matter abnormalities in major depressive disorder with melancholic and atypical features: A diffusion tensor imaging study
White matter abnormalities in major depressive disorder with melancholic and atypical features: A diffusion tensor imaging study
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DOI：
10.1111/pcn.12255
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发表时间：
2015-06-01
影响因子：
11.9
通讯作者：
Kunugi, Hiroshi
中科院分区：
文献类型：
--
作者：
Ota, Miho;Noda, Takamasa;Kunugi, Hiroshi
目的DSM-IV对重度抑郁症（MDD）的一些亚型进行了识别。众所周知，抗抑郁药的疗效在不同的重度抑郁症亚型之间是不同的，因此亚型的区分是很重要的。然而，与具有忧郁特征的MDD （mMDD）相比，具有非典型特征的MDD （aMDD）的大脑结构变化知之甚少，这促使我们研究这两种亚型之间弥散张量成像（DTI）评估白质完整性的可能差异。方法选取mMDD患者21例，aMDD患者24例，年龄和性别匹配的健康志愿者37例，通过1.5特斯拉磁共振成像获得DTI数据。我们比较了两个诊断组和健康受试者的各向异性分数和平均扩散系数值，这些值来自于逐体素的DTI数据。结果与正常人相比，重度抑郁症患者胼胝体、额枕下束和左上纵束的各向异性分数显著降低，平均扩散率显著升高。然而，我们在mMDD和aMDD之间的任何脑区都没有发现显着差异。结论MDD患者部分脑白质完整性降低；然而，在aMDD和mMDD之间没有主要的区别。
AimThe DSM-IV recognizes some subtypes of major depressive disorder (MDD). It is known that the effectiveness of antidepressants differs among the MDD subtypes, and thus the differentiation of the subtypes is important. However, little is known as to structural brain changes in MDD with atypical features (aMDD) in comparison with MDD with melancholic features (mMDD), which prompted us to examine possible differences in white matter integrity assessed with diffusion tensor imaging (DTI) between these two subtypes.MethodsSubjects were 21 patients with mMDD, 24 with aMDD, and 37 age- and sex-matched healthy volunteers whose DTI data were obtained by 1.5 tesla magnetic resonance imaging. We compared fractional anisotropy and mean diffusivity value derived from DTI data on a voxel-by-voxel basis among the two diagnostic groups and healthy subjects.ResultsThere were significant decreases of fractional anisotropy and increases of mean diffusivity in patients with MDD compared with healthy subjects in the corpus callosum, inferior fronto-occipital fasciculus, and left superior longitudinal fasciculus. However, we detected no significant difference in any brain region between mMDD and aMDD.ConclusionOur results suggest that patients with MDD had reduced white matter integrity in some regions; however, there was no major difference between aMDD and mMDD.