FASTING STUDIES IN CEREBROSPINAL-FLUID AND BLOOD IN CHILDREN WITH EPILEPSY OF UNKNOWN ORIGIN
FASTING STUDIES IN CEREBROSPINAL-FLUID AND BLOOD IN CHILDREN WITH EPILEPSY OF UNKNOWN ORIGIN
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DOI：
10.1016/0920-1211(95)00011-x
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发表时间：
1995-05-01
影响因子：
2.2
通讯作者：
DOESBURG, WH
中科院分区：
文献类型：
--
作者：
LAMERS, KJB;GABREELS, FJM;DOESBURG, WH
脑能供应的改变很可能引起脑功能紊乱。禁食是研究能量代谢的一种合适的方法。脑脊液（CSF）室反映脑代谢，脑脊液的数据可能提供脑内燃料底物代谢的信息。我们比较了病因不明的癫痫儿童（6-15岁）禁食40小时后雏鸟和脑脊液中几种燃料相关成分的生化数据与参照组儿童的值。原发性全身性癫痫患儿未见异常。复杂部分性癫痫患儿有许多明显的异常，如低血乳酸、低丙氨酸、低脑脊液酮和低脑脊液酮血比。对观察到的异常可能的意义进行了讨论。
Alterations in the cerebral energy supply are likely to cause cerebral function disturbances. Fasting is a suitable method for studying the energy metabolism. As the cerebrospinal fluid (CSF) compartment reflects the brain metabolism, data in CSF might give information about the metabolism of fuel substrates in brain. We compared the biochemical data on several fuel-related components in brood and CSF at the end of a 40-hours fast of epileptic children with unknown origin of epilepsy (aged 6-15 years) with the values of a reference group of children. In children with primary generalized epilepsy no abnormalities were found. In children with complex partial epilepsy many significant abnormalities were found, such as low blood lactate and alanine and low CSF ketones and CSF blood ratio for ketones. The possible significance of the observed abnormalities are discussed.