Accurate Monte Carlo simulation of frequency-domain optical coherence tomography
Accurate Monte Carlo simulation of frequency-domain optical coherence tomography
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DOI：
10.1002/cnm.3177
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发表时间：
2019-04-01
影响因子：
2.1
通讯作者：
Bai, Li
中科院分区：
文献类型：
--
作者：
Wang, Yan;Bai, Li
光学相干断层扫描 (OCT) 依靠光学干涉测量来提供活体组织的无创成像。除了用于医学诊断的 3D 成像能力之外，研究人员还探索了其在恢复生物组织光学参数以进行生物和病理分析方面的潜在用途，因为组织的病理变化会改变组织的微观结构，从而改变其光学特性。我们的目标是通过从 OCT 扫描中估计组织的光学特性（在扫描中不可见）来开发一种新的 OCT 数据分析方法。这是一个逆问题。解决逆问题涉及正向建模步骤，以利用假设的光学参数值来模拟组织的 OCT 扫描，以及逆向步骤，以通过将模拟扫描与真实扫描相匹配来估计真实光学参数值。在本文中，我们提出了一种基于蒙特卡罗 (MC) 的频域 OCT 仿真方法。我们采用聚焦高斯光束而不是无限细光束来进行精确模拟。还实施了一种新的、更准确的光子检测方案。我们将 MC 模型与基于扩展惠更斯-菲涅耳原理 (EHF) 的分析 OCT 模型进行比较，以证明两个模型之间的一致性。我们表明，对于具有高散射和高各向异性因子的组织，这两个模型非常一致。
Optical coherence tomography (OCT) relies on optical interferometry to provide noninvasive imaging of living tissues. In addition to its 3D imaging capacity for medical diagnosis, its potential use for recovering optical parameters of biological tissues for biological and pathological analyses has also been explored by researchers, as pathological changes in tissue alter the microstructure of the tissue and therefore its optical properties. We aim to develop a new approach to OCT data analysis by estimating optical properties of tissues from OCT scans, which are invisible in the scans. This is an inverse problem. Solving an inverse problem involves a forward modeling step to simulate OCT scans of the tissues with hypothesized optical parameter values and an inverse step to estimate the real optical par1meters values by matching the simulated scans to real scans. In this paper, we present a Monte Carlo (MC)-based approach for simulating the frequency-domain OCT. We incorporated a focusing Gaussian light beam rather than an infinitesimally thin light beam for accurate simulations. A new and more accurate photon detection scheme is also implemented. We compare our MC model to an analytical OCT model based on the extended Huygens-Fresnel principle (EHF) to demonstrate the consistency between the two models. We show that the two models are in good agreement for tissues with high scattering and high anisotropy factors.