Trends in the incidence rates of nasopharyngeal carcinoma among Chinese Americans living in Los Angeles County and the San Francisco metropolitan area, 1992-2002
Trends in the incidence rates of nasopharyngeal carcinoma among Chinese Americans living in Los Angeles County and the San Francisco metropolitan area, 1992-2002
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DOI：
10.1093/aje/kwi345
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发表时间：
2005-12-15
影响因子：
5
通讯作者：
Weiss, NS
中科院分区：
文献类型：
--
作者：
Sun, LM;Epplein, M;Weiss, NS
鼻咽癌在亚洲国家比在西方国家更为常见。然而，自1980年代以来，香港男女鼻咽癌的发病率均有所下降，最近新加坡亦有类似的趋势。使用来自监测、流行病学和最终结果项目和美国人口普查的数据，作者评估了居住在洛杉矶县和旧金山-奥克兰（加州）大都市区的中国人鼻咽癌发病率的近期趋势。从1992年到2002年，这两个人群的鼻咽癌发病率在男性中下降了37%(95%可信区间：-54，-12)，而在女性中仅下降了1%（95%可信区间：-40,64）。在中国男性中，发病率的总体下降主要局限于I型肿瘤（分化鳞状肿瘤，产生角蛋白）发病率的下降。虽然观察到的发病率模式背后的原因仍有待确定，但生活方式和环境的变化可能是促成因素。
Nasopharyngeal carcinoma is much more common in Asian countries than in Western countries. However, since the 1980s, nasopharyngeal carcinoma incidence has fallen among both men and women in Hong Kong, and recently a similar trend has also been noted in Singapore. Using data from the Surveillance, Epidemiology, and End Results Program and the US Census, the authors evaluated recent trends in the incidence rates of nasopharyngeal carcinoma among Chinese living in Los Angeles County and in the San Francisco-Oakland (California) metropolitan area. From 1992 to 2002, the rates of nasopharyngeal carcinoma in these two populations decreased in men by 37% (95% confidence interval: -54, -12) but in women by just 1% (95% confidence interval: -40, 64). In Chinese men, the overall decline in incidence was limited primarily to a decline in the rate of type I tumors (differentiated squamous tumors with keratin production). While the reasons underlying the observed patterns of incidence remain to be determined, changes in lifestyle and environment are likely to be contributory factors.