Caffeine modulates attention network function
Caffeine modulates attention network function
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DOI：
10.1016/j.bandc.2009.07.013
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发表时间：
2010-03-01
影响因子：
2.5
通讯作者：
Taylor, Holly A.
中科院分区：
文献类型：
--
作者：
Brunye, Tad T.;Mahoney, Caroline R.;Taylor, Holly A.
本工作研究了咖啡因（0 mg. 100毫克，200毫克，400毫克）的侧翼任务，旨在测试波斯纳的三个视觉注意网络功能：报警，定向，和执行控制[波斯纳，M。I.（2004年）。注意力的认知神经科学。纽约，纽约：吉尔福德出版社]。在一项使用重复测量设计的安慰剂对照双盲研究中，我们发现咖啡因对视觉注意力的影响随剂量和注意力网络的变化而变化。咖啡因以剂量反应方式改善警觉和执行控制功能，在200 mg时逐渐消失;这种效果与咖啡因对大脑富含多巴胺区域的腺苷介导的作用以及这些区域参与警觉和视觉注意力的执行控制一致。较高剂量的咖啡因也导致在任务执行期间视觉注意力向提示区域的分配效率略低（即，定向）。总之，这项研究的结果表明，咖啡因对视觉注意力网络的不同影响作为剂量的函数，这种影响对咖啡因，腺苷和多巴胺在介导视觉注意力的大脑区域中的假设相互作用有影响。爱思唯尔公司出版
The present work investigated the effects of caffeine (0 mg. 100 mg, 200 mg, 400 mg) on a flanker task designed to test Posner's three visual attention network functions: alerting, orienting, and executive control [Posner, M. I. (2004). Cognitive neuroscience of attention. New York, NY: Guilford Press]. In a placebo-controlled, double-blind study using a repeated-measures design, we found that the effects of caffeine on visual attention vary as a function of dose and the attention network under examination. Caffeine improved alerting and executive control function in a dose-response manner, asymptoting at 200 mg; this effect is congruent with caffeine's adenosine-mediated effects on dopamine-rich areas of brain, and the involvement of these areas in alerting and the executive control of visual attention. Higher doses of caffeine also led to a marginally less efficient allocation of visual attention towards cued regions during task performance (i.e., orienting). Taken together, results of this study demonstrate that caffeine has differential effects on visual attention networks as a function of dose, and such effects have implications for hypothesized interactions of caffeine, adenosine and dopamine in brain areas mediating visual attention. Published by Elsevier Inc.