Selective impairment of action-verb naming and comprehension in progressive supranuclear palsy
Selective impairment of action-verb naming and comprehension in progressive supranuclear palsy
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DOI：
10.1016/j.cortex.2012.03.024
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发表时间：
2013-04-01
期刊：
影响因子：
3.6
通讯作者：
Gainotti, Guido
中科院分区：
文献类型：
--
作者：
Daniele, Antonio;Barbier, Annalisa;Gainotti, Guido
先前对脑损伤患者的一些研究表明，左颞叶的神经系统可能在名词的产生和理解中起关键作用，而前额叶后皮层的类似系统可能参与动词的产生和理解。我们评估了10名进行性核上性麻痹（PSP）患者和10名年龄匹配的健康对照者在名词和动作动词的产生和理解方面的神经心理学任务的表现。PSP患者还使用99mtc -乙基半胱氨酸二聚体，通过单光子发射计算机断层扫描（SPECT）测量局部脑血流。在所有PSP患者中，SPECT显示额下回（IFG）明显灌注不足。除了名词的听觉词汇决策任务外，PSP患者在所有词汇语义任务上的表现都明显差于对照组。然而，在PSP患者中，在各种词汇语义任务（口头和书面对峙命名，听觉和视觉单字理解）中，动作动词的表现明显低于名词。个体表现分析揭示了不同PSP患者神经心理障碍的异质性模式。尽管很难得出关于功能损伤位置的明确结论，但我们假设，在大多数PSP患者中，这种选择性产生和理解动作动词的损伤可能是由于影响动作概念类别的语义缺陷。这些发现与之前的假设一致，即在PSP中，处理动作概念范畴的关键神经系统后额叶皮质区（主要涉及IFG）的功能障碍可能导致动作动词的产生和理解选择性受损。(C) 2012 Elsevier Ltd.版权所有。
Some previous studies in brain-damaged patients suggested that neural systems in the left temporal lobe might be crucial in the production and comprehension of nouns, while analogous systems in posterior frontal cortical areas might be involved in the production and comprehension of verbs. We assessed performance on neuropsychological tasks of production and comprehension of nouns and action-verbs in 10 patients with progressive supranuclear palsy (PSP) and in 10 age-matched healthy controls. PSP patients also underwent measurements of regional cerebral blood flow by means of single photon emission computed tomography (SPECT), using 99mTc-Ethyl Cysteinate Dimer. In all PSP patients, SPECT showed a significant hypoperfusion in the inferior frontal gyrus (IFG). PSP patients performed significantly worse than controls on all lexical semantic tasks, except for the auditory lexical decision task on nouns. Within PSP patients, however, a significantly lower performance was observed on action-verbs as compared to nouns on various lexical semantic tasks (oral and written confrontation naming, auditory and visual single-word comprehension). Analysis of individual performance revealed heterogeneous patterns of neuropsychological impairment in different PSP patients. Despite some difficulty in drawing clear-cut conclusions about the locus of functional damage, we hypothesise that in most of our PSP patients such selective impairment in the production and in the comprehension of action-verbs could be due to semantic deficits affecting the Conceptual category of actions. These findings are consistent with the hypothesis that in PSP a dysfunction of neural systems in posterior frontal cortical areas (mainly involving the IFG) critical for processing the conceptual category of actions might result in a selective impairment of production and comprehension of action-verbs. (C) 2012 Elsevier Ltd. All rights reserved.