Chlamydia pneumoniae infection in patients with chronic obstructive pulmonary disease
Chlamydia pneumoniae infection in patients with chronic obstructive pulmonary disease
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DOI：
10.1017/s095026889600725x
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发表时间：
1997-04-01
影响因子：
4.2
通讯作者：
Saikku, P
中科院分区：
文献类型：
--
作者：
VonHertzen, L;Alakarppa, H;Saikku, P
对54例确诊的慢性阻塞性肺疾病(COPD)患者、41例重度COPD患者(I组)、13例轻至中度COPD患者(II组)和23例社区获得性肺炎患者(III组)的慢性肺炎衣原体感染情况进行了评估。检测配对血清中特异性免疫球蛋白抗体(Ig G)、特异性免疫球蛋白A抗体(Ig A)和循环免疫复合物(IC)水平，以及痰标本中特异性分泌性Ig A(SIgA)水平。采用聚合酶链式反应(PCR)检测痰标本中肺炎衣原体。根据我们的明确诊断标准，65%的COPD患者有疑似慢性肺炎衣原体感染的证据，重症患者的患病率更高(71%)。感染的特定标志物在重度COPD患者中的发生率总是最高的，在轻中度COPD患者中次之，在肺炎患者中最低。在控制了潜在的混杂因素后，COPD和肺炎衣原体感染之间的关联仍然存在。
The prevalence of chronic Chlamydia pneumoniae infection was assessed in 54 patients with established chronic obstructive pulmonary disease (COPD), 41 of these with severe COPD (group I), 13 with mild to moderate COPD (group II), and in 23 patients with community-acquired pneumonia (controls, group III). Specific IgG and IgA antibody levels and circulating immune complexes (ICs) were measured in paired sera, and specific secretory IgA (sIgA) levels in sputum specimens. A polymerase chain reaction (PCR) test was used for the detection of C. pneumoniae in sputum. According to our definite diagnosis criterion, 65 % of the COPD patients showed evidence of suspected chronic C. pneumoniae infection and the prevalence was still higher (71 %) in patients with severe disease. The occurrence of specific markers of infection was invariably highest in patients with severe COPD, next-highest in patients with mild to moderate COPD and lowest in pneumonia patients. The association between COPD and C. pneumoniae infection persisted after controlling for the potential confounding factors.