The hemopoietic colony stimulating factors
The hemopoietic colony stimulating factors
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造血集落刺激因子
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
D. Metcalf
中科院分区：
文献类型：
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作者：
D. Metcalf
血细胞的连续形成可能受特异性体液调节因子的控制，这一概念得到了早期证据的支持，即一种称为促红细胞生成素的体液因子参与红细胞生成的调节（Carnot和Deflandre，1906）。然而，直到1966年引入在半固体培养中生长正常造血细胞集落的方法，才在鉴定和表征其他造血群体的相应特异性调节剂方面取得进展。
The concept that the continuous formation of blood cells might be under the control of specific humoral regulatory factors received early support from the demonstration that a humoral factor, termed erythropoietin, was involved in the regulation of erythropoiesis (Carnot and Deflandre, 1906). However it was not until the introduction in 1966 of methods for growing colonies of normal hemopoietic cells in semisolid culture, that progress was made in identifying and characterizing corresponding specific regulators for other hemopoietic populations.