FAMILY HISTORY AS AN INDEPENDENT RISK FACTOR FOR INCIDENT CORONARY-ARTERY DISEASE IN A HIGH-RISK COHORT IN UTAH
FAMILY HISTORY AS AN INDEPENDENT RISK FACTOR FOR INCIDENT CORONARY-ARTERY DISEASE IN A HIGH-RISK COHORT IN UTAH
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DOI：
10.1016/0002-9149(88)91206-4
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发表时间：
1988-10-01
影响因子：
2.8
通讯作者：
ASH, KO
中科院分区：
文献类型：
--
作者：
HOPKINS, PN;WILLIAMS, RR;ASH, KO
为了检验冠状动脉疾病家族史（CAD）作为新型临床CAD发展危险因素的独立性，采用Cox比例危险度法分析了1196名年龄在bb0 ~ 20岁的男性和女性的2次门诊就诊数据。在平均2.5年的随访期间，观察到16例新的CAD病例。在调整年龄、性别、总胆固醇、高密度脂蛋白胆固醇、高血压、糖尿病、吸烟和体重指数后，家族史仍然是未来CAD的高度显著预测因子（p = 0.0017）。只有年龄是比家族史更重要的协变量（p = 0.0001）。性别（p = 0.0074）和血清总胆固醇（p = 0.015）也对冠心病发病率有显著影响，而高密度脂蛋白胆固醇、高血压、糖尿病、体重指数和几个相互作用项对该人群的预测没有改善。这些结果为存在其他遗传风险因素提供了证据，这些因素似乎在许多高危家庭中对早期CAD的发生起着重要作用。
To test the independence of family history of coronary artery disease (CAD) as a risk factor for the development of new clinical CAD, data collected at 2 clinic visits on 1,196 men and women, ages > 20 years, were analyzed using Cox proportional hazard method. During a mean follow-up of 2.5 years, 16 new CAD cases were observed. After adjustment for age, sex, total cholesterol, high density lipoprotein cholesterol, hypertension, diabetes, cigarette smoking and body mass index, family history remained a highly significant predictor of future CAD (p = 0.0017). Only age was a more significant covariate (p = 0.0001) than family history. Sex (p = 0.0074) and serum total cholesterol (p = 0.015) also contributed significantly to CAD incidence while high density lipoprotein cholesterol, hypertension, diabetes, body mass index and several interaction terms did not improve the prediction in this population. These results provide evidence for the existence of other heritable risk factors which appear to contribute strongly to the occurrence of early CAD in many high-risk families.