Expression of microRNAs: potential molecular link between obesity, diabetes and cancer
Expression of microRNAs: potential molecular link between obesity, diabetes and cancer
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DOI：
10.1111/j.1467-789x.2011.00906.x
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发表时间：
2011-12-01
期刊：
影响因子：
8.9
通讯作者：
Sarkar, F. H.
中科院分区：
文献类型：
--
作者：
Ali, A. S.;Ali, S.;Sarkar, F. H.
由于肥胖和糖尿病的复杂性，临床医生在癌症患者的管理中经常受到挑战，这些疾病通常被发现为合并症。尽管对这些患者的优化治疗计划给予了关注，但对他们的肥胖和糖尿病管理的关注却很少。这表明，必须开发更新、全面的方法来治疗癌症患者，而不是将其作为一种单一的疾病。虽然每种疾病的具体病理都是独特的，但多年的研究表明，这些慢性疾病之间存在密切的分子联系。久坐不动的生活方式和不良的饮食习惯是公认的；然而，精确的分子联系仍然没有得到很好的探索。此外，新出现的证据表明，microRNAs （miRNAs）在几种疾病的发生和发展中起着重要作用，但它们在肥胖、糖尿病和癌症之间的作用现在才开始被认识到。mirna有望成为新的生物标志物和分子靶点，用于癌症合并症患者的治疗。在这篇综述中，我们讨论了目前对肥胖、糖尿病和癌症的病理生物学的理解，并记录了mirna在癌症与肥胖和糖尿病之间的分子作用。
Clinicians are routinely challenged in their management of cancer patients because of the complexities of obesity and diabetes that are often found as comorbid conditions. Although attention has been given to optimizing treatment planning for these patients, less attention has been given to manage their obesity and diabetes. This suggests that newer, comprehensive approaches must be developed for the treatment of cancer patients as a whole rather than as a single disease. While the specific pathologies of each are unique, years of research have indicated intimate molecular links between these chronic diseases. The contribution of sedentary lifestyles and poor dietary habits is recognized; however, the precise molecular links are still not well-explored. In addition, emerging evidence suggests the important role of microRNAs (miRNAs) in the development and progression of several diseases, yet their roles in linking obesity, diabetes and cancer are only now beginning to be recognized. It is hoped that miRNAs will serve as novel biomarkers and molecular targets for cancer therapy in patients with comorbid conditions. In this review, we discuss the current understanding of the pathobiology of obesity, diabetes and cancer, and document molecular roles of miRNAs linking cancer with obesity and diabetes.