Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology.

Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology.
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DOI:
10.1016/j.ceb.2020.03.002
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发表时间:
2020-04
影响因子:
7.5
通讯作者:
Wu H
Wu H
中科院分区:
生物学2区
文献类型:
--
作者:
Shi M;Zhang P;Vora SM;Wu H

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被称为信号体的高阶超分子复合体在先天免疫和炎症中执行关键的信号和效应功能。在这篇综述中,我们介绍了几个最近发现的信号小体,它们要么是通过稳定的蛋白质相互作用形成的,要么是通过动态液-液相分离形成的。重点介绍了这些信号体的结构特征,以阐明它们的功能和生物学意义。
Higher-order supramolecular complexes dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein-protein interactions or by dynamic liquid-liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.
朊病毒样聚合是抗病毒免疫防御和炎症小体激活中信号转导的基础。
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