Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology.
Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology.
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DOI:
10.1016/j.ceb.2020.03.002
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发表时间:
2020-04
影响因子:
7.5
通讯作者:
Wu H
中科院分区:
文献类型:
--
作者:
Shi M;Zhang P;Vora SM;Wu H
Higher-order supramolecular complexes dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein-protein interactions or by dynamic liquid-liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.
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