Abnormal intracellular modulation of calcium as a major cause of cardiac contractile dysfunction.
Abnormal intracellular modulation of calcium as a major cause of cardiac contractile dysfunction.
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细胞内钙调节异常是心脏收缩功能障碍的主要原因。
DOI：
10.1056/nejm199108293250906
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Morgan,JP
中科院分区：
文献类型：
--
作者：
Morgan,JP
细胞内钙离子的释放和再摄取对哺乳动物心脏的正常收缩和舒张功能是必需的。钙离子在调节心脏兴奋-收缩偶联和收缩与舒张周期中所起的中心作用如图1.1，2所示。改变心脏收缩状态的钙依赖性机制主要有两种：改变肌丝对钙的利用率和改变肌丝对细胞内钙激活的反应性。细胞内钙的有效性由肌膜和肌浆网调节，钙反应性由肌丝和肌浆网控制。
THE release and reuptake of intracellular calcium are necessary to the normal systolic and diastolic function of the mammalian heart. The central part played by calcium ions in regulating excitation–contraction coupling and cycles of contraction and relaxation in the heart is diagrammed in Figure 1.1,2There are two major calcium-dependent mechanisms that alter the contractile state of the heart: changing the availability of calcium to the myofilaments, and changing the responsiveness of the myofilaments to activation by intracellular calcium. The availability of intracellular calcium is regulated by the sarcolemma and sarcoplasmic reticulum, and calcium responsiveness is controlled by the myofilaments and . . .