Plasma concentrations of interleukin-1-beta, interleukin-6 and tumor necrosis factor-alpha, and of their soluble receptors and receptor antagonist in anorexia nervosa
Plasma concentrations of interleukin-1-beta, interleukin-6 and tumor necrosis factor-alpha, and of their soluble receptors and receptor antagonist in anorexia nervosa
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DOI：
10.1016/s0165-1781(01)00283-9
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发表时间：
2001-09-20
影响因子：
11.3
通讯作者：
Franceschi, C
中科院分区：
文献类型：
--
作者：
Brambilla, F;Monti, D;Franceschi, C
白细胞介素-1 β（IL-1 β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）可诱导厌食症以及多种行为和生化改变，这些改变与神经性厌食症相似。然而，在文献中的报告，包含对比数据的分泌模式的三种细胞因子和下游活动的受体和受体拮抗剂在神经性厌食症。我们检测了血浆中IL-1 β、IL-6、TNF-α、可溶性IL-6受体W（sIL-6-R）、可溶性TNF-α受体I和II（s-TNF-α-R-I和II）和可溶性IL-1 β受体拮抗剂14例女性神经性厌食症患者血清s-IL-1 β-R-A水平（9个限制者，5个狂欢/净化者）和13个年龄和性别匹配的健康对照受试者，以观察循环细胞因子浓度和细胞因子活性的下游步骤是否受损，以及这些变化是否与疾病的某些方面相关。与对照组相比，神经性厌食症患者血浆中IL-1 β、IL-6、TNF-α、s-TNF-α-R-I和-II以及sIL-1 β-RA的浓度无显著差异。血清sIL-6-R水平在厌食症组明显低于正常对照组，但在两种亚型间无显著性差异。sIL-6-R改变的病因学意义尚不清楚，但结合文献中细胞因子功能的最新数据，这一发现表明促炎细胞因子途径的损伤可能参与神经性厌食症的发展。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) induce anorexia, and multiple behavioral and biochemical alterations that mimic those of anorexia nervosa. Reports in the literature, however, contain contrasting data on the pattern of secretion of the three cytokines and on the downstream activities of their receptors and receptor antagonists in anorexia nervosa. We measured plasma concentrations of IL-1 beta, IL-6, TNF-alpha, soluble IL-6 receptor W(sIL-6-R), soluble TNF-alpha receptors I and II (s-TNF-alpha -R-I and II), and soluble IL-1 beta receptor antagonist (s-IL-1 beta -R-A) in 14 female patients with anorexia nervosa (nine restricters, five binge/purgers) and in 13 age- and sex-matched healthy control subjects to see whether the circulating cytokine concentrations and the downstream steps of cytokine activity were impaired, and if these alterations were correlated with some aspects of the disease. Concentrations of IL-1 beta, IL-6, TNF-alpha, s-TNF-alpha -R-I and -II and sIL-1 beta -RA in plasma did not differ significantly in patients with anorexia nervosa compared with control subjects. Concentrations of sIL-6-R were significantly lower in the patients than in the control subjects, but there were no differences between the two sub-types of anorexia nervosa. The etiopathogenetic significance of the sIL-6-R alteration is not clear, but together with recent data in the literature oil cytokine function, the finding suggests that an impairment of the pro-inflammatory cytokine pathway might be involved in the development of anorexia nervosa. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.