Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis
Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis
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DOI：
10.1002/hep.510270132
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发表时间：
1998-01-01
期刊：
影响因子：
13.5
通讯作者：
Thomas, HC
中科院分区：
文献类型：
--
作者：
Foster, GR;Goldin, RD;Thomas, HC
在没有肝硬化的情况下，慢性丙型肝炎病毒（HCV）感染对患者生活质量的影响使用简明36（SF 36）生活学问卷进行评估。慢性丙型肝炎患者有多症状，并且在所有测试的模式下其SF 36评分均显著降低，慢性B型肝炎病毒（HBV）感染患者的SF 36评分（评估心理功能）降低，但他们的躯体症状评分没有降低，表明与慢性HCV感染相关的症状在性质上不同于与慢性HBV感染相关的症状，过去曾使用静脉内药物的慢性HCV感染患者的生活质量评分受损最大，但在从未使用药物的患者中仍发现生活质量评分的降低，生活质量的降低不能归因于肝脏炎症的程度或感染的获得方式，因此，HCV慢性感染本身引起降低感染患者生活质量的身体症状。
The effects of chronic hepatitis C virus (HCV) infection, in the absence of cirrhosis, on patients' quality of life was assessed using the short form 36 (SF36) symptomatology questionnaire, Patients with chronic hepatitis C were polysymptomatic and had significant reductions in their SF36 scores for all of the modalities tested, Patients with chronic hepatitis B virus (HBV) infection showed a reduction in the SF36 scores that assessed mental functions, but they had no decrease in the scores that measured physical symptoms, indicating that the symptoms associated with chronic HCV infection are qualitatively different from those associated with chronic HBV infection, Patients with chronic HCV infection who had used intravenous drugs in the past had the greatest impairment in quality-of-life scores, but the reduction in quality-of-life scores was still found in patients who had never used drugs, The reduction in quality of life could not be attributed to the degree of liver inflammation or to the mode of acquisition of the infection, Hence, chronic infection with HCV per se gives rise to physical symptoms that reduce the quality of life of infected patients.