Golgi protein 73, not Glypican-3, may be a tumor marker complementary to α-Fetoprotein for hepatocellular carcinoma diagnosis
Golgi protein 73, not Glypican-3, may be a tumor marker complementary to α-Fetoprotein for hepatocellular carcinoma diagnosis
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DOI：
10.1111/jgh.12461
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发表时间：
2014-03-01
影响因子：
4.1
通讯作者：
Mao, Yilei
中科院分区：
文献类型：
--
作者：
Wang, Yichen;Yang, Huayu;Mao, Yilei
背景与目的探讨血清高尔基体蛋白73（Golgi protein 73，GP 73）和磷脂酰肌醇蛋白聚糖3（Glypican-3，GPC-3）在肝细胞癌（Hepatocellular carcinoma，HCC）诊断中的价值。根据既定的临床程序进行诊断。检测血清GP 73、GPC-3和甲胎蛋白。绘制受试者工作特征（ROC）曲线，以确定各血清标志物及其组合的敏感性和特异性。GP 73与AFP作为肝癌诊断标志物的差异无统计学意义。但在小肝癌的诊断中，GP 73比AFP更敏感。GP 73和AFP联合检测可提高HCC诊断的敏感性和特异性。联合检测的ROC曲线下面积（AUC）为0.93，而GP 73单独检测的AUC为0.88，AFP单独检测的AUC为0.90。84例HCC患者GPC-3检测均为阴性。GPC-3的AUC为0.43，表明血清GPC-3不是诊断肝癌的有效肿瘤标志物。结论血清GP 73是诊断肝癌的潜在肿瘤标志物，特别是对于小肝癌和肝硬化的鉴别诊断。GP 73与AFP联合检测的敏感性高于AFP单独检测。血清GPC-3似乎不是诊断HCC的有效肿瘤标志物。
Background and AimThis study aimed to evaluate the effectiveness of serum Golgi protein 73 (GP73) and Glypican-3 (GPC-3) as tumor markers for diagnosis of hepatocellular carcinoma (HCC).MethodsA total of 257 subjects were enrolled and consisted of 61 healthy controls, 32 hepatitis B virus carriers, 80 cirrhosis patients, and 84 HCC patients. Diagnosis was performed based on established clinical procedure. Serum GP73, GPC-3, and -fetoprotein were measured. Receiving operating characteristic (ROC) curves were plotted to determine the sensitivity and specificity of each serum marker and their combinations.ResultSerum GP73 levels were significantly increased in HCC patients. No significant differences were observed between GP73 and -fetoprotein (AFP) as markers for HCC diagnosis. However, GP73 was more sensitive than AFP in the diagnosis of small HCC. A combination of GP73 and AFP tests increased the sensitivity and specificity for HCC diagnosis. The area under the ROC curve (AUC) of combined test was 0.93 compared with 0.88 for GP73 and 0.90 for AFP alone. GPC-3 tests were negative in all 84 HCC patients. The AUC for GPC-3 is 0.43, indicating that serum GPC-3 was not an effective tumor marker for HCC diagnosis.ConclusionSerum GP73 is a potential tumor marker for HCC diagnosis, especially for differential diagnosis of small HCC and cirrhosis. The combination of GP73 and AFP is more sensitive than AFP alone. Serum GPC-3 does not appear to be an effective tumor marker for HCC diagnosis.