Thickening of the carotid wall - A marker for atherosclerosis in the elderly?
Thickening of the carotid wall - A marker for atherosclerosis in the elderly?
复制标题
DOI：
10.1161/01.str.27.2.224
复制
发表时间：
1996-02-01
期刊：
影响因子：
8.3
通讯作者：
Furberg, CD
中科院分区：
文献类型：
--
作者：
OLeary, DH;Polak, JF;Furberg, CD
背景与目的我们研究了老年人群中常见的冠心病(CHD)、临床表现的动脉粥样硬化性疾病(ASD)与颈总动脉(CCA)和颈内动脉(ICA)内膜中层厚度(IMT)之间的关系。我们希望确定无创性测量是否可以作为临床上明显的动脉粥样硬化性疾病的指标，并确定两个变量中的哪一个，CCA IMT或ICA IMT是更好的相关性。方法采用双功能超声测量5117名参加心血管健康研究的5117人的CCA和ICA的IMT，这项研究是关于65岁或以上成年人心血管疾病的危险因素和自然病史的研究。在基线检查中获得了冠心病、外周动脉疾病和脑血管疾病的病史。风险因素包括胆固醇水平。吸烟、高血压、糖尿病？年龄和性别。采用多元回归分析和规范变量分析研究危险因素与IMT的关系。对颈总动脉和颈内动脉IMT测量结果进行Logistic回归分析，预测颈总动脉和颈内动脉IMT的患病率。
Background and Purpose We investigated the relationships between prevalent coronary heart disease (CHD), clinically manifest atherosclerotic disease (ASD), and major established risk factors for atherosclerosis and intima-media thickness (IMT) in the common carotid arteries (CCA) and internal carotid arteries (ICA) separately and in combination in older adults. We wished to determine whether a noninvasive measurement can serve as an indicator of clinically manifest atherosclerotic disease and to determine which of the two variables, CCA IMT or ICA IMT, is a better correlate.Methods IMT of the CCA and ICA was measured with duplex ultrasound in 5117 of 5201 individuals enrolled in the Cardiovascular Health Study, a study of the risk factors and the natural history of cardiovascular disease in adults aged 65 years or more. Histories of CHD, peripheral arterial disease, and cerebrovascular disease were obtained during baseline examination. Risk factors included cholesterol levels. cigarette smoking, elevated blood pressure, diabetes? age, and sex. Relationships between risk factors and IMT were studied by multiple regression analysis and canonical variate analysis. Prediction of prevalent CHD and ASD by IMT measurements in CCAs and ICAs were made by logistic regression, adjusting for age and sex.Results IMT measurements of the CCAs and ICAs were greater in persons with CHD and ASD than those without, even after controlling for sex (P