Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: A randomized placebo-controlled double-blind study
Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: A randomized placebo-controlled double-blind study
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DOI：
10.1067/mob.2003.41
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发表时间：
2003-02-01
影响因子：
9.8
通讯作者：
Zugaib, M
中科院分区：
文献类型：
--
作者：
da Fonseca, EB;Bittar, RE;Zugaib, M
目的：本研究的目的是评估预防性阴道孕酮在降低早产率在高危population.Study设计：随机，双盲，安慰剂对照研究包括142高危单胎妊娠的效果。孕激素（100毫克）或安慰剂，每天阴道栓剂和所有患者进行子宫收缩监测与外部分娩力计每周一次，60分钟，妊娠24至34周之间。比较了预后组（n = 72）和安慰剂组（n = 70）的流行病学特征、子宫收缩频率和早产发生率。结果：早产率为21.1%（30/142）。孕酮组和安慰剂组的子宫活动度存在差异（分别为23.6%和54.3%; P
OBJECTIVE: The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population.STUDY DESIGN: A randomized, double-blind, placebo-controlled study included 142 high-risk singleton pregnancies. Progesterone (100 mg) or placebo was administered daily by vaginal suppository and all patients underwent uterine contraction monitoring with an external tocodynamometer once a week for 60 minutes, between 24 and 34 weeks of gestation. Progesterone (n = 72) and placebo (n = 70) groups were compared for epidemiologic characteristics, uterine contraction frequency, and incidence of preterm birth. Data were compared by chi(2) analysis and Fisher exact test.RESULTS: The preterm birth rate was 21.1% (30/142). Differences in uterine activity were found between the progesterone and placebo groups (23.6% vs 54.3%, respectively; P