Multifaceted regulation of T cells by CD44.
Multifaceted regulation of T cells by CD44.
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DOI：
10.4161/cib.3.6.13495
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发表时间：
2010-11-01
影响因子：
--
通讯作者：
Bradley, Linda M
中科院分区：
文献类型：
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作者：
Baaten, Bas Jg;Li, Cheng-Rui;Bradley, Linda M
CD44是一种广泛表达的粘附受体，与涉及迁移细胞的多种生物学过程相关，包括炎症、血管生成、骨代谢和伤口愈合。在免疫系统中，在初始T淋巴细胞对入侵微生物的应答期间，初始T淋巴细胞活化后，CD44上调。一旦感染被清除，升高水平的CD44保留在记忆T细胞表面，介导对再感染的保护。虽然这导致使用T细胞上高度持续的CD44表达作为先前免疫应答的指标，但与T细胞应答或稳态的相关性在很大程度上尚未探索。我们最近的研究表明，CD44选择性地调节CD4 T细胞的Th1亚群的存活，而不是其他T细胞亚群。这些发现，以及其他细胞类型中CD44的研究表明，信号传导机制的参与差异可能是T细胞反应差异调节的基础，并强调了这种粘附受体对免疫细胞调节和保护免受病毒和细胞内细菌的重要性。
CD44 is a widely-expressed adhesion receptor that is associated with diverse biological processes involving migrating cells, including inflammation, angiogenesis, bone metabolism and wound healing. In the immune system, CD44 is upregulated after activation of naive T lymphocytes during their responses against invading microbes. Once an infection is cleared, elevated levels of CD44 remain on the surface of memory T cells that mediate protection against re-infection. While this has led to the use of highly sustained CD44 expression on T cells as an indicator of a previous immune response, the relevance to T-cell responses or homeostasis has been largely unexplored. Our recent studies demonstrate that CD44 selectively regulates the survival of the Th1 subset of CD4 T cells, but not other T-cell subpopulations. These findings, together with studies of CD44 in other cell types, suggest that differences in the engagement of signaling mechanisms are likely to underlie differential regulation of T-cell responses and underscore the importance of this adhesion receptor to immune cell regulation and protection against viruses and intracellular bacteria.