In vivo evaluation of bone-bonding of titanium metal chemically treated with a hydrogen peroxide solution containing tantalum chloride.
In vivo evaluation of bone-bonding of titanium metal chemically treated with a hydrogen peroxide solution containing tantalum chloride.
复制标题
用含有氯化钽的过氧化氢溶液进行化学处理的钛金属的骨结合的体内评估。
DOI：
10.1016/s0142-9612(01)00036-9
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发表时间：
2001
期刊：
影响因子：
14
通讯作者：
A. Osaka
中科院分区：
文献类型：
--
作者：
S. Kaneko;K. Tsuru;S. Hayakawa;S. Takemoto;C. Ohtsuki;T. Ozaki;H. Inoue;A. Osaka
种植体上的磷灰石形成对于实现与骨组织的直接结合非常重要。我们最近表明，用含有氯化钽的过氧化氢溶液化学处理的钛金属具有在具有与人血浆相似的无机离子组成的模拟体液中形成羟基磷灰石层的能力。本研究将经此方法处理的纯钛圆柱体（直径4.0mm，长20.0mm）植入兔胫骨上直径4.2mm的孔中。植入16周后，取出骨组织样本，通过推出试验检测植入物与骨组织之间的剪切力。结果与未处理的纯钛进行了比较。术后8周，尽管表面粗糙度在处理后没有改变，但处理后的钛植入4. 2mm孔中的剪切力显著高于未处理的钛。扫描电子显微镜（SEM）观察和能量色散X射线（EDX）显微分析表明，骨非常接近处理后的钛表面。在4. 0mm孔中植入的试样剪切力大于4. 2mm孔中植入的试样剪切力。因此，证实了用含有氯化钽的过氧化氢溶液处理可在体内对钛植入物提供更高的结合能力。
Apatite formation on implants is important in achieving a direct bonding to bone tissue. We recently showed that titanium metal chemically treated with a hydrogen peroxide solution containing tantalum chloride has the ability to form a hydroxyapatite layer in simulated body fluid which had inorganic ion composition similar to human blood plasma. In this study, a pure titanium cylinder (4.0mm in diameter, 20.0mm in length) treated with this method was implanted into a hole (4.2mm in diameter) in a rabbit's tibia. After implantation for predetermined periods up to 16 weeks, the specimens were extracted with bone tissue, and were examined by push-out test to evaluate the shearing force between the implant and bone tissue. The results were compared with those of non-treated pure titanium. Eight weeks after surgery, the shearing force of the treated titanium implanted in the 4.2mm-hole was significantly higher than that of non-treated titanium, although the surface roughness was not changed after the treatment. Scanning electron microscopic (SEM) observation and energy-dispersive X-ray (EDX) microanalysis showed that the bone comes very close to the surface of the treated titanium. Moreover, the shearing force was higher for the implanted sample in the 4.0mm-hole than that in the 4.2mm-hole. Thus, it is confirmed that the treatment with hydrogen peroxide solution containing tantalum chloride provides higher bonding ability on titanium implants in vivo.