CutDB: a proteolytic event database.
CutDB: a proteolytic event database.
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DOI：
10.1093/nar/gkl813
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
中科院分区：
文献类型：
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除了蛋白水解机制在蛋白质降解和周转中众所周知的作用外，许多特异性蛋白酶在各种调节过程中起着关键作用。数以千计的高度特异性蛋白水解事件与正常和病理状况相关，包括细菌和病毒感染。然而，有关单个蛋白水解事件的信息分散在多篇文献中，不易用于大规模分析。CutDB是最早系统性地努力为体内或体外天然蛋白质构建一个易于获取的已记录蛋白水解事件集合的数据库之一。一个CutDB条目由以下三个属性的独特组合来定义：蛋白酶、蛋白质底物和切割位点。目前，CutDB整合了从公共档案库（如MEROPS和HPRD）以及文献中获取的470种不同蛋白酶的3070个蛋白水解事件。CutDB支持各种类型的数据搜索和展示，包括可点击的网络图。最重要的是，CutDB是一个基于维基百科方法的社区注释资源，提供了一个方便的用户界面用于在线输入新数据。该领域几位专家最近贡献了568个基质金属肽酶相关的蛋白水解事件，这表明这种方法将显著加速CutDB内容的发展。CutDB可在以下网址公开获取：。
Beyond the well-known role of proteolytic machinery in protein degradation and turnover, many specialized proteases play a key role in various regulatory processes. Thousands of highly specific proteolytic events are associated with normal and pathological conditions, including bacterial and viral infections. However, the information about individual proteolytic events is dispersed over multiple publications and is not easily available for large-scale analysis. CutDB is one of the first systematic efforts to build an easily accessible collection of documented proteolytic events for natural proteins in vivo or in vitro. A CutDB entry is defined by a unique combination of these three attributes: protease, protein substrate and cleavage site. Currently, CutDB integrates 3070 proteolytic events for 470 different proteases captured from public archives (such as MEROPS and HPRD) and publications. CutDB supports various types of data searches and displays, including clickable network diagrams. Most importantly, CutDB is a community annotation resource based on a Wikipedia approach, providing a convenient user interface to input new data online. A recent contribution of 568 proteolytic events by several experts in the field of matrix metallopeptidases suggests that this approach will significantly accelerate the development of CutDB content. CutDB is publicly available at .