Midsagittal tissue bridges are associated with walking ability in incomplete spinal cord injury: A magnetic resonance imaging case series
Midsagittal tissue bridges are associated with walking ability in incomplete spinal cord injury: A magnetic resonance imaging case series
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DOI：
10.1080/10790268.2018.1527079
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发表时间：
2020-03-03
影响因子：
1.7
通讯作者：
Smith, Andrew C.
中科院分区：
文献类型：
--
作者：
O'Dell, Denise R.;Weber, Kenneth A.;Smith, Andrew C.
背景：脊髓损伤（SCI）后，由于脊髓休克、镇静、即将手术和继发性长骨骨折等因素，早期预测未来的行走能力是困难的。在脊髓损伤急性期使用准确、客观的生物标志物将为个性化的患者管理提供信息，并提高患者/家属的期望和治疗结果。利用磁共振成像（MRI）和正中矢状面t2加权图像，组织桥架的数量（以脊髓组织的剩余量来测量）显示出作为这种生物标志物的潜力。10例完全性脊髓损伤患者接受脊髓MRI检查。利用正中矢状面t2加权图像，计算前后组织桥作为脑脊液到损伤的距离。然后，计算正中矢状面组织桥比值为前后组织桥之和除以脊髓直径。每个参与者还进行了6分钟的步行测试，其中步行的总距离是在6分钟内测量的。结果：正中矢状面组织桥比测量显示了高水平的评估间可靠性（ICC = 0.90）。中矢状面组织桥比率与6分钟步行距离显著相关（R = 0.68, P = 0.03）。
Context: Following spinal cord injury (SCI), early prediction of future walking ability is difficult, due to factors such as spinal shock, sedation, impending surgery, and secondary long bone fracture. Accurate, objective biomarkers used in the acute stage of SCI would inform individualized patient management and enhance both patient/family expectations and treatment outcomes. Using magnetic resonance imaging (MRI) and specifically a midsagittal T2-weighted image, the amount of tissue bridging (measured as spared spinal cord tissue) shows potential to serve as such a biomarker. Ten participants with incomplete SCI received MRI of the spinal cord. Using the midsagittal T2-weighted image, anterior and posterior tissue bridges were calculated as the distance from cerebrospinal fluid to the damage. Then, the midsagittal tissue bridge ratio was calculated as the sum of anterior and posterior tissue bridges divided by the spinal cord diameter. Each participant also performed a 6-minute walk test, where the total distance walked was measured within six minutes. Findings: The midsagittal tissue bridge ratio measure demonstrated a high level of inter-rater reliability (ICC = 0.90). Midsagittal tissue bridge ratios were significantly related to distance walked in six minutes (R = 0.68, P = 0.03).