Long-term survival in 463 women treated with platinum analogs for advanced epithelial carcinoma of the ovary: life expectancy compared to women of an age-matched normal population
Long-term survival in 463 women treated with platinum analogs for advanced epithelial carcinoma of the ovary: life expectancy compared to women of an age-matched normal population
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DOI：
10.1111/j.1048-891x.2004.014507.x
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发表时间：
2004-09-01
影响因子：
4.8
通讯作者：
Rustin, GJS
中科院分区：
文献类型：
--
作者：
Lambert, HE;Gregory, WM;Rustin, GJS
目的是评估463名患有IIb-IV期卵巢上皮癌的妇女的长期生存率（5-15年），并将其生存率与年龄和性别匹配的正常人群进行比较。对463名患有IIb-IV期卵巢上皮癌的妇女进行了统计分析，这些妇女参加了1985年至1994年进行的两项连续的北泰晤士卵巢组随机试验。中位随访期为10.5年。在可能的情况下，这些妇女接受了减瘤手术和辅助铂化疗。在第一次北泰晤士试验中，其中一个随机分组也接受了全腹部放疗。评估了5年、10年和15年的生存率。使用数学模型确定长期生存的预后因素，以区分早期效应和晚期效应。计算与正常人群相比，观察到的死亡与预期死亡的比值。5年总生存率为21%（95%置信区间17.5-25%），10年为13.5%（95%置信区间10.5-17%），15年为12%（95%置信区间9-16%）。长期生存的重要预后因素是无病或微小残留病变（单个残留存款
The objective was to assess the long-term survival (5-15 years) in 463 women, with stages IIb-IV epithelial carcinoma of the ovary and to compare their survival with that of a normal population matched for age and sex. Statistical analysis of 463 women, with stages IIb-IV epithelial cancer of the ovary, who were participants in two consecutive North Thames Ovary Group randomized trials, which took place between 1985 and 1994, was performed. The median follow-up period was 10.5 years. The women were treated with debulking surgery, where possible, and adjuvant platinum chemotherapy. One of the randomized groups in the first North Thames trial also received total abdominal radiotherapy. Survival rates at 5, 10, and 15 years were assessed. Prognostic factors for long-term survival were determined using a mathematical model to separate early effects from late effects. The ratio of observed to expected deaths compared to the normal population was calculated. Overall survival at 5 years was 21% (95% confidence intervals 17.5-25%), at 10 years was 13.5% (95% confidence intervals 10.5-17%), and at 15 years was 12% (95% confidence intervals 9-16%). The important prognostic factors for long-term survival were disease-free or minimal residual disease (a single remaining deposit