Deficits in prospective memory following damage to the prefrontal cortex
Deficits in prospective memory following damage to the prefrontal cortex
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DOI：
10.1016/j.neuropsychologia.2011.03.036
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发表时间：
2011-07
期刊：
影响因子：
2.6
通讯作者：
S. Umeda;Yoshiko Kurosaki;Yuri Terasawa;Motoichiro Kato;Yasuyuki Miyahara
中科院分区：
文献类型：
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作者：
S. Umeda;Yoshiko Kurosaki;Yuri Terasawa;Motoichiro Kato;Yasuyuki Miyahara
前瞻记忆（PM）是对未来意图或计划的记忆，其神经心理学研究在过去二十年中得到了发展。在项目管理中被广泛接受的划分包括前瞻性记忆组件（PMC），一个记住要记住的过程，和回顾性记忆组件，一个记住预期动作内容的过程。先前的功能性神经影像学研究已经提供了一些证据，表明吻侧前额叶皮层（BA10）是前瞻记忆的关键区域之一。然而，部分前额叶皮层的损伤是否影响PMC的减弱表现的问题仍未得到解决。在这项研究中，74名创伤性脑损伤（TBI）包括额叶或颞叶区域局灶性损伤的参与者进行了13项标准神经心理测试和PM任务。为了确定对项目管理绩效有影响的领域，进行了判别函数分析。结果表明，以下三个区域对PM表现有重要贡献：右背外侧前额叶皮层；右腹内侧前额叶皮层；左前额叶背内侧皮层。比较神经心理测试分数的差异表明，在PM表现更好的组中，定向得分显著更高，这表明PMC代表了与当前状态意识相关的综合记忆功能。这些数据有助于我们了解PMC的神经基质和功能特征。
Neuropsychological investigations of prospective memory (PM), representing memory of future intentions or plans, have evolved over the past two decades. The broadly accepted divisions involved in PM consist of a prospective memory component (PMC), a process for remembering to remember, and a retrospective memory component, a process for remembering the content of the intended action. Previous functional neuroimaing studies have provided some evidence that the rostral prefrontal cortex (BA10) is one of areas that is critical for prospective remembering. However, the question of whether damage to part of the prefrontal cortex affects attenuated performance for PMC remains unresolved. In this study, 74 participants with traumatic brain injury (TBI) including focal damage to frontal or temporal lobe areas were administered thirteen standard neuropsychological tests and the PM task. To identify influential areas contributing to PM performance, discriminant function analysis was conducted. The results indicated that the following three areas are highly contributory to PM performance: the right dorsolateral prefrontal cortex; the right ventromedial prefrontal cortex; and the left dorsomedial prefrontal cortex. Comparing differences in neuropsychological test scores showed that orientation scores were significantly higher in the greater PM performance group, suggesting that PMC represents an integrated memory function associated with awareness of current status. These data contribute to our understanding of the neural substrates and functional characteristics of the PMC.