LOXL2 Inhibitors and Breast Cancer Progression.
LOXL2 Inhibitors and Breast Cancer Progression.
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DOI：
10.3390/antiox10020312
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发表时间：
2021-02-19
期刊：
影响因子：
--
通讯作者：
Fernandes AS
中科院分区：
文献类型：
--
作者：
Ferreira S;Saraiva N;Rijo P;Fernandes AS
LOX（赖氨酰氧化酶）和赖氨酰氧化酶样-1-4（LOXL 1-4）是胺氧化酶，其催化结缔组织中弹性蛋白和胶原的交联反应。这些胺氧化酶还允许肿瘤细胞外基质中胶原蛋白和弹性蛋白的交联，促进细胞迁移和转移形成的过程。LOXL 2在癌症生物学中特别令人感兴趣，因为它在一些肿瘤中高度表达。这种蛋白质还促进致癌转化并影响乳腺癌细胞的增殖。因此，LOX和LOXL 2抑制被认为是预防乳腺癌转移和侵袭的有希望的策略。BAPN（β-氨基丙腈）是第一个被描述为LOX抑制剂的化合物，并且从天然来源获得。然而，最近已经开发了用作LOX/LOXL 2选择性抑制剂或用作双重LOX/LOX-L抑制剂的新型合成化合物。在这篇综述中，我们描述了LOX酶及其在促进癌症发展和转移中的作用，特别关注LOXL 2和乳腺癌进展。此外，还讨论了LOXL 2抑制剂开发的最新进展。总的来说，这项工作将LOXL 2抑制作为乳腺癌治疗的一种有前途的新的补充和有效的治疗方法，并探讨了其重要性。
LOX (lysyl oxidase) and lysyl oxidase like-1–4 (LOXL 1–4) are amine oxidases, which catalyze cross-linking reactions of elastin and collagen in the connective tissue. These amine oxidases also allow the cross-link of collagen and elastin in the extracellular matrix of tumors, facilitating the process of cell migration and the formation of metastases. LOXL2 is of particular interest in cancer biology as it is highly expressed in some tumors. This protein also promotes oncogenic transformation and affects the proliferation of breast cancer cells. LOX and LOXL2 inhibition have thus been suggested as a promising strategy to prevent metastasis and invasion of breast cancer. BAPN (β-aminopropionitrile) was the first compound described as a LOX inhibitor and was obtained from a natural source. However, novel synthetic compounds that act as LOX/LOXL2 selective inhibitors or as dual LOX/LOX-L inhibitors have been recently developed. In this review, we describe LOX enzymes and their role in promoting cancer development and metastases, with a special focus on LOXL2 and breast cancer progression. Moreover, the recent advances in the development of LOXL2 inhibitors are also addressed. Overall, this work contextualizes and explores the importance of LOXL2 inhibition as a promising novel complementary and effective therapeutic approach for breast cancer treatment.
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影响因子：
11.4
作者：
Flórido A;Saraiva N;Cerqueira S;Almeida N;Parsons M;Batinic-Haberle I;Miranda JP;Costa JG;Carrara G;Castro M;Oliveira NG;Fernandes AS
通讯作者：
Fernandes AS
影响因子：
3.7
作者：
Bondareva A;Downey CM;Ayres F;Liu W;Boyd SK;Hallgrimsson B;Jirik FR
通讯作者：
Jirik FR
影响因子：
11.2
作者：
Grossman, Moran;Ben-Chetrit, Nir;Sagi, Irit
通讯作者：
Sagi, Irit
影响因子：
20.3
作者：
Bignon, Marine;Pichol-Thievend, Cathy;Germain, Stephane
通讯作者：
Germain, Stephane
影响因子：
5.2
作者：
Hase, Hiroaki;Jingushi, Kentaro;Tsujikawa, Kazutake
通讯作者：
Tsujikawa, Kazutake