Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance.
Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance.
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DOI：
10.2337/dc09-1392
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发表时间：
2010-07
期刊：
影响因子：
16.2
通讯作者：
Study of the Health Assessment And Risk Evaluation in Aboriginal Peoples Investigators
中科院分区：
文献类型：
--
作者：
Mente A;Razak F;Blankenberg S;Vuksan V;Davis AD;Miller R;Teo K;Gerstein H;Sharma AM;Yusuf S;Anand SS;Study of the Health Assessment And Risk Evaluation;Study of the Health Assessment And Risk Evaluation in Aboriginal Peoples Investigators
研究脂联素和瘦素浓度的种族差异，并确定这些脂肪因子和高血糖指数饮食是否解释了胰岛素抵抗的种族差异。对1176名南亚人、中国人、原住民和欧洲裔加拿大人进行了空腹血样采集，并使用标准化问卷记录了临床病史和饮食习惯，包括血糖指数/血糖负荷。胰岛素抵抗定义采用稳态模型评估-胰岛素抵抗（HOMA-IR）。欧洲人（校正平均12.94 [95% CI 2.27-13.64]）和土著居民（11.87[11.19-12.59]）的脂联素浓度显著高于南亚人（9.35[8.82-9.92]）和中国人（8.52[8.03-9.03]）（总P < 0.001）。南亚人（11.82[10.72-13.04]）和土著人（11.13[10.13-12.23]）的血清瘦素显著高于欧洲人（9.21[8.38-10.12]）和中国人（8.25[7.48-9.10]）。除南亚人外，其他各组BMI和腰围与脂联素呈负相关（相互作用P < 0.001）。脂联素与HOMA-IR呈负相关，瘦素与HOMA-IR呈正相关（P < 0.001）。脂联素每降低一次，南亚人（P = 0.01）和土著居民（P < 0.001）的HOMA-IR增加幅度大于欧洲人。与其他人群相比，南亚人（P = 0.03）和土著居民（P < 0.001）的高血糖指数与脂联素下降幅度较大相关，南亚人的HOMA-IR增加幅度较大（P < 0.05）。南亚人的脂肪因子水平最低，与土著居民一样，他们的胰岛素抵抗水平更高，脂联素水平下降。脂肪因子的差异和对升糖食物的反应与胰岛素抵抗的种族差异相似。
To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high–glycemic index diet account for ethnic variation in insulin resistance. In 1,176 South Asian, Chinese, Aboriginal, and European Canadians, fasting blood samples were drawn, and clinical history and dietary habits including glycemic index/glycemic load were recorded using standardized questionnaires. Insulin resistance was defined using homeostasis model assessment–insulin resistance (HOMA-IR). Adiponectin concentrations were significantly higher in Europeans (adjusted mean 12.94 [95% CI 2.27–13.64]) and Aboriginal people (11.87 [11.19–12.59]) than in South Asians (9.35 [8.82–9.92]) and Chinese (8.52 [8.03–9.03]) (overall P < 0.001). Serum leptin was significantly higher in South Asians (11.82 [10.72–13.04]) and Aboriginal people (11.13 [10.13–12.23]) than in Europeans (9.21 [8.38–10.12]) and Chinese (8.25 [7.48–9.10]). BMI and waist circumference were inversely associated with adiponectin in every group except the South Asians (P < 0.001 for interaction). Adiponectin was inversely and leptin was positively associated with HOMA-IR (P < 0.001). The increase in HOMA-IR for each given decrease in adiponectin was larger among South Asians (P = 0.01) and Aboriginal people (P < 0.001) than among Europeans. A high glycemic index was associated with a larger decrease in adiponectin among South Asians (P = 0.03) and Aboriginal people (P < 0.001) and a larger increase in HOMA-IR among South Asians (P < 0.05) relative to that in other groups. South Asians have the least favorable adipokine profile and, like the Aboriginal people, display a greater increase in insulin resistance with decreasing levels of adiponectin. Differences in adipokines and responses to glycemic foods parallel the ethnic differences in insulin resistance.