Valuation Survey of EQ-5D-Y Based on the International Common Protocol: Development of a Value Set in Japan.
Valuation Survey of EQ-5D-Y Based on the International Common Protocol: Development of a Value Set in Japan.
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DOI：
10.1177/0272989x211001859
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发表时间：
2021-07
期刊：
影响因子：
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通讯作者：
Stolk E
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文献类型：
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作者：
Shiroiwa T;Ikeda S;Noto S;Fukuda T;Stolk E
EQ-5D-Y是针对儿童和青少年（8-15岁）的基于偏好的测量。这是第一项开发EQ-5D-Y值集以将EQ-5D-Y反应转换为指数值的研究。我们从日本5个城市的普通人群中招募了1047名受访者（年龄20-79岁），按性别和年龄组分层。所有数据均通过面对面调查收集。受访者被要求从代理人的角度使用复合时间权衡（cTTO）和离散选择实验（DCE）来评估一个假设的10岁儿童的EQ-5D-Y状态。使用混合logit模型分析离散选择数据。然后通过将潜在DCE值映射到cTTO值，将其转换为0（死亡）/1（完全健康）量表。最差健康状态[33333]的平均观察cTTO值为0.20。对DCE数据的分析表明，与心理功能相关的领域（“感到疼痛或不适”和“感到担心、悲伤或不快乐”）的系数大于与身体和社会功能相关的领域。通过将潜在DCE值转换为效用量表，我们构建了EQ-5D-Y的值集。未发现不一致之处。最小预测评分为0.288 [33333]，次佳评分为0.957 [12111]。成功构建了EQ-5D-Y的数值集。这是EQ-5D-Y值集的首次调查。解释EQ-5D-Y和EQ-5D-5L值集之间的差异是未来的任务，对医疗保健政策有影响。
EQ-5D-Y is a preference-based measure for children and adolescents (aged 8–15 y). This is the first study to develop an EQ-5D-Y value set for converting EQ-5D-Y responses to index values. We recruited 1047 respondents (aged 20–79 y) from the general population, stratified by gender and age group, in 5 Japanese cities. All data were collected through face-to-face surveys. Respondents were asked to value EQ-5D-Y states for a hypothetical 10-y-old child from a proxy perspective using composite time tradeoff (cTTO) and a discrete choice experiment (DCE). The discrete choice data were analyzed using a mixed logit model. Latent DCE values were then converted to a 0 (death)/1 (full health) scale by mapping them to the cTTO values. The mean observed cTTO value of the worst health state [33333] was 0.20. Analysis of the DCE data showed that the coefficients of the domains related to mental functions (“Having pain or discomfort” and “Feeling worried, sad, or unhappy”) were larger than those for the domains related to physical and social functions. By converting latent DCE values to a utility scale, we constructed a value set for EQ-5D-Y. No inconsistencies were observed. The minimum predicted score was 0.288 [33333], and the second-best score was 0.957 [12111]. A value set for EQ-5D-Y was successfully constructed. This is the first survey of an EQ-5D-Y value set. Interpreting the differences between EQ-5D-Y and EQ-5D-5L value sets is a future task with implications for health care policy.