Plasma calcitonin in normal man. Differences between men and women.
Plasma calcitonin in normal man. Differences between men and women.
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正常人的血浆降钙素。
DOI：
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发表时间：
1977
影响因子：
15.9
通讯作者：
G. Sizemore
中科院分区：
文献类型：
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作者：
H. Heath;G. Sizemore
我们用放射免疫测定法测定了健康志愿者（20名男性，年龄23-45岁，平均30岁; 25名女性，年龄21-46岁，平均30岁）的血浆降钙素浓度，该放射免疫测定法能够检测5 pg降钙素/500穆尔孵育体积或25 pg/ml未提取血浆。所有受试者均接受4小时钙输注（15 mg Ca/kg），24名受试者在不同日期接受静脉注射五肽胃泌素（0.5 μ g/kg）。男性的基础血浆免疫反应性降钙素浓度高于女性（P < 0.001）：平均值分别为49 pg/ml（范围，<25-73）和31 pg/ml（范围，<25-51）。20名男性中有18名（90%）对诱导的高钙血症有反应，血浆免疫反应性降钙素增加; 25名女性中只有14名（56%）有反应。在男性中，血浆免疫反应性降钙素+/-SE的平均增加为58+/-9 pg/ml，但女性仅为25+/-6 pg/ml。10名男性中有8名（80%）对五肽胃泌素有反应，血浆免疫反应性降钙素增加>30 pg/ml，而14名女性中只有1名（7%）有这种反应。这些血浆降钙素免疫反应的性别差异有统计学意义（钙输注，P < 0.02;五肽胃泌素，P < 0.001）。这些观察结果的生理重要性尚不清楚，但我们推测，在某些女性中，降钙素的终身相对缺乏可能在年龄和性别相关的骨丢失中发挥作用，特别是在雌激素缺乏的绝经后岁月。
We measured plasma calcitonin concentrations in healthy volunteers (20 men, ages 23-45 yr, mean, 30 yr; 25 women, ages 21-46 yr, mean, 30 yr) with a radioimmunoassay capable of detecting 5 pg of calcitonin/500 mul incubation volume, or 25 pg/ml of unextracted plasma. All subjects had 4-h calcium infusion (15 mg Ca/kg), and 24 subjects had intravenous pentagastrin injection (0.5 mug/kg) on separate days. Men had higher basal plasma immunoreactive calcitonin concentrations than women (P < 0.001): mean, 49 pg/ml (range, <25-73) and 31 pg/ml (range, <25-51), respectively. 18 of the 20 men (90%) responded to induced hypercalcemia with increases in plasma immunoreactive calcitonin; only 14 of the 25 women (56%) responded. In men, the mean increase of plasma immunoreactive calcitonin+/-SE was 58+/-9 pg/ml, but for women was only 25+/-6 pg/ml. 8 of 10 men (80%) responded to pentagastrin with an increase of plasma immunoreactive calcitonin >30 pg/ml, compared with such a response in only 1 of 14 women (7%). These differences of plasma immunoreactive calcitonin responses between the sexes were statistically significant (calcium infusion, P < 0.02; pentagastrin, P < 0.001). The physiologic importance of these observations is unknown, but we speculate that a lifelong, relative deficiency of calcitonin in some women could play a role in age- and sex-related bone loss, particularly during the estrogen-deficient postmenopausal years.