Colistin past and future: A bibliographic analysis
Colistin past and future: A bibliographic analysis
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DOI：
10.1016/j.jcrc.2012.04.008
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发表时间：
2013-04-01
影响因子：
3.7
通讯作者：
Thomas, David W.
中科院分区：
文献类型：
--
作者：
Azzopardi, Ernest A.;Ferguson, Elaine L.;Thomas, David W.
目的：粘菌素是一种古老的药物，由于多药耐药（MDR）和有效抗生素的短缺，它重新引起了人们的兴趣。我们综合了耐多药感染、粘菌素及其不良事件的出版趋势，作为衡量医学学术界兴趣的指标，为当前的再开发策略提供信息。设计：这是一个超过50年的多数据库电子搜索，通过Web of Knowledge进行前后参考。研究分为耐多药、粘菌素和不良事件，并以5年为组进行分组。结果：1940 ~ 1975年三个时期的文献趋势较为明显；B， 1975年至2000年；C， 00后。A时期的特点是出版物增多，随后不久出现了以不利影响为主题的出版物。B期报告了出版物的急剧下降；C期报告兴趣急剧增加，反映了MDR文献的指数增长。B期先于标准化的现代药理学要求。C时期与新型药物开发技术相吻合。讨论：确定了两种当前趋势（时期C）。当前配方的优化可能受到b时期的影响。目前在这一趋势下的研究工作包括药代动力学/药效学分析、纯化、配方和耐药性监测。第二种趋势涉及粘菌素的再开发，通过量身定制的化学再造来生产新颖和可专利的化学实体，并强调跨学科的方法。希望对这一粘菌素案例研究的历史趋势和当前再开发策略之间的相互作用的分析可以突出为干燥抗生素管道提供动力的策略。爱思唯尔公司版权所有版权所有。
Objective: Colistin is a venerable drug that has found renewed interest because of multidrug resistance (MDR) and the shortfall of effective antibiotics. We present a synthesis of publication trends on MDR infection, colistin, and its adverse events, as a measure of the medical-academic community's interest, to inform current redevelopment strategies.Design: This was a multidatabase electronic search over 50 years with back-and forward-referencing through Web of Knowledge. Studies were grouped into MDR, colistin, and adverse events and were plotted in 5-year clusters.Results: Three periods could be mapped with distinct literature trends: A, 1940 to 1975; B, 1975 to 2000; and C, post-2000. Period A was characterized by increasing publications, soon followed by adverse-effect-themed publications. Period B reported a sharp publication decline; and period C reported a sharp increase in interest, mirroring the exponential increase in MDR literature. Period B predated standardized modern pharmacologic requirements. Period C coincided with novel drug development techniques.Discussion: Two current trends (period C) were identified. Optimization of the current formulation may have been influenced by period B. Current research efforts within this trend include pharmacokinetic/pharmacodynamic analysis, purification, formulation, and resistance surveillance. The second trend involved colistin's redevelopment by tailored chemical reengineering to produce novel and patentable chemical entities, with an interdisciplinary approach emphasis. It is hoped that an analysis of the interplay between historical trends and current redevelopment strategies of this colistin case study may highlight strategies to stoke the drying antibiotic pipeline. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.