Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders.
Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders.
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深入了解 CSF1R 在中枢神经系统和神经系统疾病中的作用
DOI：
10.3389/fnagi.2021.789834
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发表时间：
2021
影响因子：
4.8
通讯作者：
Zheng H
中科院分区：
文献类型：
--
作者：
Hu B;Duan S;Wang Z;Li X;Zhou Y;Zhang X;Zhang YW;Xu H;Zheng H
The colony-stimulating factor 1 receptor (CSF1R) is a key tyrosine kinase transmembrane receptor modulating microglial homeostasis, neurogenesis, and neuronal survival in the central nervous system (CNS). CSF1R, which can be proteolytically cleaved into a soluble ectodomain and an intracellular protein fragment, supports the survival of myeloid cells upon activation by two ligands, colony stimulating factor 1 and interleukin 34. CSF1R loss-of-function mutations are the major cause of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and its dysfunction has also been implicated in other neurodegenerative disorders including Alzheimer’s disease (AD). Here, we review the physiological functions of CSF1R in the CNS and its pathological effects in neurological disorders including ALSP, AD, frontotemporal dementia and multiple sclerosis. Understanding the pathophysiology of CSF1R is critical for developing targeted therapies for related neurological diseases.
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骨髓细胞 2 上表达的触发受体 (TREM2) 与集落刺激因子 1 受体 (CSF1R) 相互作用，但对于 CSF1/CSF1R 介导的小胶质细胞存活不是必需的
影响因子：
7.3
作者：
Cheng B;Li X;Dai K;Duan S;Rong Z;Chen Y;Lü L;Liu Z;Huang X;Xu H;Zhang YW;Zheng H
通讯作者：
Zheng H
影响因子：
15.1
作者：
Barth M;Bacioglu M;Schwarz N;Novotny R;Brandes J;Welzer M;Mazzitelli S;Häsler LM;Schweighauser M;Wuttke TV;Kronenberg-Versteeg D;Fog K;Ambjørn M;Alik A;Melki R;Kahle PJ;Shimshek DR;Koch H;Jucker M;Tanriöver G
通讯作者：
Tanriöver G
耦合的增殖和凋亡维持成人大脑中小胶质细胞的快速离职。
影响因子：
8.8
作者：
Askew K;Li K;Olmos-Alonso A;Garcia-Moreno F;Liang Y;Richardson P;Tipton T;Chapman MA;Riecken K;Beccari S;Sierra A;Molnár Z;Cragg MS;Garaschuk O;Perry VH;Gomez-Nicola D
通讯作者：
Gomez-Nicola D
影响因子：
2.9
作者：
Barreda, DR;Hanington, PC;Belosevic, M
通讯作者：
Belosevic, M
DOI：
10.2463/mrms.mp.2016-0016
发表时间：
2017-10-10
期刊：
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
影响因子：
--
作者：
Abe T;Kawarai T;Fujita K;Sako W;Terasawa Y;Matsuda T;Sakai W;Tsukamoto-Miyashiro A;Matsui N;Izumi Y;Kaji R;Harada M
通讯作者：
Harada M