Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration.
Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration.
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DOI：
10.1016/0959-4388(93)90157-t
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发表时间：
1993-10-01
影响因子：
5.7
通讯作者：
Bunge, R P
中科院分区：
文献类型：
--
作者：
Bunge, R P
雪旺细胞在承担广泛的功能方面表现出显著的多功能性。现在已经很清楚，众所周知的鞘鞘和髓鞘形成的功能是通过与轴突的接触来特异性调节的，雪旺细胞主要参与周围神经干的细胞外基质的产生，雪旺细胞在促进周围神经系统轴突再生方面起着关键作用。雪旺细胞在许多中枢神经元中促进再生的能力使得使用雪旺细胞自体移植物修复中枢神经系统的兴趣越来越大。
Schwann cells show remarkable versatility in undertaking a broad repertoire of functions. It is now clear that the well known functions of ensheathment and myelination are specifically regulated by contact with axons, that the Schwann cell is centrally involved in extracellular matrix production in the peripheral nerve trunk, and that the Schwann cell plays a critical role in promoting axonal regeneration in the peripheral nervous system. The Schwann cell's ability to promote regenerative efforts in many central neurons has led to an increasing interest in using Schwann cell autografts for central nervous system repair.