Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa
Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa
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DOI：
10.1111/j.1462-2920.2010.02173.x
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发表时间：
2010-05-01
影响因子：
5.1
通讯作者：
Kolter, Roberto
中科院分区：
文献类型：
--
作者：
Klepac-Ceraj, Vanja;Lemon, Katherine P.;Kolter, Roberto
囊性纤维化（CF）患者的多微生物支气管肺炎感染可导致进行性肺损伤和死亡.虽然铜绿假单胞菌的到来往往预示着一个更快的速度肺下降，有显着的下降速度的个体间差异，其原因仍然知之甚少。通过将非培养方法与生态学分析相结合，我们发现了45例CF儿童呼吸道细菌群落特征与临床疾病标志物之间的相关性。细菌群落复杂性与患者年龄、是否存在铜绿假单胞菌和抗生素暴露呈负相关，并与CF基因型相关。引人注目的是，无论抗生素暴露如何，缺乏铜绿假单胞菌的细菌群落比含有铜绿假单胞菌的细菌群落彼此更加相似。这表明，社区组成可能是一个更好的预测疾病进展比单独存在铜绿假单胞菌，值得进一步研究。
P>Polymicrobial bronchopulmonary infections in cystic fibrosis (CF) cause progressive lung damage and death. Although the arrival of Pseudomonas aeruginosa often heralds a more rapid rate of pulmonary decline, there is significant inter-individual variation in the rate of decline, the causes of which remain poorly understood. By coupling culture-independent methods with ecological analyses, we discovered correlations between bacterial community profiles and clinical disease markers in respiratory tracts of 45 children with CF. Bacterial community complexity was inversely correlated with patient age, presence of P. aeruginosa and antibiotic exposure, and was related to CF genotype. Strikingly, bacterial communities lacking P. aeruginosa were much more similar to each other than were those containing P. aeruginosa, regardless of antibiotic exposure. This suggests that community composition might be a better predictor of disease progression than the presence of P. aeruginosa alone and deserves further study.