Changes in explicit memory associated with early dementia in adults with Down's syndrome
Changes in explicit memory associated with early dementia in adults with Down's syndrome
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DOI：
10.1046/j.1365-2788.2002.00365.x
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发表时间：
2002-03-01
影响因子：
3.6
通讯作者：
Silverman, WP
中科院分区：
文献类型：
--
作者：
Krinsky-McHale, SJ;Devenny, DA;Silverman, WP
背景选择性提醒测验（SRT）的改良版（Buschke 1973）用于检查患有智力残疾（ID）和唐氏综合征（DS）的成年人中阿尔茨海默型（DAT）早期痴呆发生的记忆变化，并将这些变化与“正常”衰老的变化进行比较。方法分层线性模型分析显示，非痴呆的参与者也表现出与他们的年龄有关的表现下降。然而，这些下降的绝对幅度与“正常”衰老模式一致，而不是与未被发现的痴呆症。结果在分析受损的特定记忆成分时，作者发现，与非痴呆症同龄人相比，早期DAT参与者显示出严重降低的长期存储和检索处理能力。值得注意的是，这些下降先于痴呆症的其他症状，在大多数情况下超过一整年，有时多达3 years.Conclusions因此，目前的结果清楚地证实，记忆过程中受到影响，在早期痴呆症的成年人与DS，和SRT有希望作为一种临床工具。
Background A modified version of the Selective Reminding Test (SRT) (Buschke 1973) was used to examine the changes in memory that occur with early-stage dementia of the Alzheimer's type (DAT) in adults with intellectual disability (ID) and Down's syndrome (DS), and to compare these changes to those occurring with 'normal' ageing.Method Hierarchical linear modelling analyses showed steep declines in the performance of participants who had met the criteria for the onset of DAT. Non-demented participants also showed declines in performance which were related to their age. However, the absolute magnitude of these declines was consistent with a 'normal' ageing pattern and not with undetected dementia.Results In analysing the specific memory components that are compromised, the present authors found that participants with early-stage DAT showed severely diminished long-term storage and retrieval processing abilities compared to their non-demented peers, Notably, these declines preceded other symptoms of dementia, in most cases by more than a full year and sometimes by as much as 3 years.Conclusions Thus, the present results clearly confirm that memory processes are affected during early dementia in adults with DS, and that the SRT has promise as a clinical tool.