Expression pattern of WWP1 in muscular dystrophic and normal chickens.
Expression pattern of WWP1 in muscular dystrophic and normal chickens.
复制标题
肌营养不良鸡和正常鸡中WWP1的表达模式。
DOI：
10.2141/jpsa.46.95
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发表时间：
2009
影响因子：
1.5
通讯作者：
H. Mannen
中科院分区：
文献类型：
--
作者：
Hirokazu Matsumoto;Hideaki Maruse;S. Sasazaki;A. Fujiwara;S. Takeda;N. Ichihara;T. Kikuchi;F. Mukai;H. Mannen
含有E3泛素蛋白连接酶1(WWP1)的WW结构域属于泛素连接酶，在泛素-蛋白酶体途径中起重要作用。此前，我们通过连锁分析和序列比对，确定WWP1基因是鸡肌营养不良症的候选基因。然而，引起病理变化和基因功能的机制仍不清楚。在本研究中，我们分析了WWP1基因在正常鸡不同肌肉和组织中的表达，并与肌肉营养不良鸡的基因表达进行了比较。在所有被检测的组织中都检测到两种mRNA亚型，并且表达水平几乎相同。营养不良鸡的WWP1在几乎所有骨骼肌中的表达都降低，包括未受影响的肌肉。这些数据表明，WWP1表达水平的改变可能与肌营养不良的严重程度之间没有因果关系。
The WW domain containing E3 ubiquitin protein ligase 1 (WWP1) is classified into one of ubiquitin ligases which play an important role in ubiquitin-proteasome pathway. Previously, we identified the WWP1 gene as a candidate gene of chicken muscular dystrophy by linkage analysis and sequence comparison. However, the mechanism causing pathological changes and underlaying gene function remains elucidated. In the present study, we analyzed the WWP1 gene expression in various muscles and tissues of normal chickens, and compared with those from muscular dystrophic chickens. Two mRNA isoforms were detected in all tissues examined and revealed almost equal expression level. The WWP1 expression of dystrophic chickens was decreased in almost all skeletal muscles including unaffected muscles. These data indicate that there might not be a causal relationship between the alteration of WWP1 expression level and the severity of muscular dystrophy.
造血转录因子 NF-E2 反式激活结构域和 WW 结构域之间的物理和功能相互作用。
影响因子：
2.9
作者：
Mosser,EA;Kasanov,JD;Forsberg,EC;Kay,BK;Ney,PA;Bresnick,EH
通讯作者：
Bresnick,EH