Effects of pulsation frequency and endothelial integrity on enhanced arterial transmural filtration produced by pulsatile pressure
Effects of pulsation frequency and endothelial integrity on enhanced arterial transmural filtration produced by pulsatile pressure
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DOI：
10.1152/ajpheart.00775.2004
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发表时间：
2005-08-01
影响因子：
4.8
通讯作者：
Wiley, E
中科院分区：
文献类型：
--
作者：
Alberding, JP;Baldwin, AL;Wiley, E
内皮细胞在脉动压力下调节跨壁液体滤过进入动脉壁的作用以及脉动频率变化对滤过的影响很少受到关注。先前的实验（Alberding JP，Baldwin AL，巴顿JK，和Wiley E. Am J Physiol Heart Circ Physiol 286：H1827-H1835，2004）证明，与通过使用在稳定压力下测量的参数预测的相比，在脉动压力的初始开始之后，滤过显著增加。为了确定内皮在该现象中的作用，对5只新西兰白色兔（用30 mg/kg戊巴比妥钠麻醉）进行了以下实验。将每对颈动脉中的一个去内皮化，并将稳定和脉动压力下的滤过测量结果与在完整血管中进行的测量结果进行比较（Alberding JP，Baldwin AL，巴顿JK和Wiley E. Am J Physiol Heart Circ Physiol 286：H1827-H1835，2004）。为了确定增加脉动频率对动脉滤过的影响，在另一组完整动脉（6条动脉和3只动物）中，通过使用1 Hz，随后2 Hz的脉动压力频率测量透壁滤过。对于去内皮化血管，脉动性开始后的滤过率初始增加与在完整血管中观察到的相似，但随后的滤过率降低不那么突然。当完整动脉的脉动频率从1 Hz增加到2 Hz时，观察到滤过率的初始增加，类似于稳定压力后脉动压力开始后获得的结果。所观察到的动脉脉动压力的反应，有和没有内皮细胞，或经历的频率变化，表明内皮细胞在体内调节经血管运输的动态作用。
The role of the endothelium in regulating transmural fluid filtration into the artery wall under pulsatile pressure and the effects of changes in pulsatile frequency on filtration have received little attention. Previous experiments (Alberding JP, Baldwin AL, Barton JK, and Wiley E. Am J Physiol Heart Circ Physiol 286: H1827-H1835, 2004) demonstrated significantly increased filtration after initial onset of pulsatile pressure compared with that predicted by using parameters measured under steady pressure. To determine the role of the endothelium in this phenomenon, the following experiments were performed on five New Zealand White rabbits (anesthetized with 30 mg/kg pentobarbital sodium). One of each pair of carotid arteries was deendothelialized, and filtration measurements under steady and pulsatile pressure were compared with those made in intact vessels (Alberding JP, Baldwin AL, Barton JK, and Wiley E. Am J Physiol Heart Circ Physiol 286: H1827-H1835, 2004). To determine the effect of increasing pulsatile frequency on arterial filtration, transmural filtration was measured by using pulsatile pressure frequencies of 1 Hz, followed by 2 Hz, in another set of intact arteries (6 arteries and 3 animals). For deendothelialized vessels, the initial increase in filtration after onset of pulsatility was similar to that observed in intact vessels, but the subsequent reduction in filtration was less abrupt. When pulsatile frequency was increased from 1 to 2 Hz in intact arteries, an initial increase in filtration was observed, similar to that obtained after onset of pulsatile pressure subsequent to a steady pressure. The observed responses of arteries to pulsatile pressure, with and without endothelium, or undergoing a frequency change, suggest a dynamic role for the endothelium in regulating transvascular transport in vivo.