Two new bicyclic sulfoxides from Welsh onion
Two new bicyclic sulfoxides from Welsh onion
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DOI：
10.1007/s11418-015-0947-z
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发表时间：
2015-12
影响因子：
3.3
通讯作者：
T. Nohara;Yukio Fujiwara;T. Ikeda;K. Murakami;M. Ono;Mona El-Aasr;Daisuke Nakano;J. Kinjo
中科院分区：
文献类型：
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作者：
T. Nohara;Yukio Fujiwara;T. Ikeda;K. Murakami;M. Ono;Mona El-Aasr;Daisuke Nakano;J. Kinjo
从大葱鳞茎的丙酮提取物中分离得到新鉴定的双环亚硫醚，分别为大葱皂苷A1(1)和A2(2)。本研究通过波谱分析对化合物1和2的结构进行了表征，它们是四氢噻吩氧化物-S-氧化物。这些化合物似乎是由1-丙烯基磺酸和糖醛酸偶联而成。Welsonin A1(1)显示了通过抑制交替激活的M2巨噬细胞的极化来抑制肿瘤细胞增殖的潜力。
Newly identified bicyclic sulfoxides, welsonins A1(1) and A2(2), were isolated from acetone extracts of the bulbs of the Welsh onion (Allium fistulosum). In this study, the structures of1and2,which are tetrahydrothiophene-S-oxide derivatives, were characterized by spectroscopic analysis. These compounds appeared to be derived from the coupling of 1-propenyl sulfenic acid and uronic acid. Welsonin A1(1) showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of alternatively activated M2 macrophages.