Phase-change material filled hollow magnetic nanoparticles for cancer therapy and dual modal bioimaging
Phase-change material filled hollow magnetic nanoparticles for cancer therapy and dual modal bioimaging
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用于癌症治疗和双模态生物成像的相变材料填充中空磁性纳米颗粒
DOI：
10.1039/c5nr01744k
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发表时间：
2015-01-01
期刊：
影响因子：
6.7
通讯作者：
Cai, Kaiyong
中科院分区：
文献类型：
--
作者：
Li, Jinghua;Hu, Yan;Cai, Kaiyong
为了开发抗癌药物的载体，本研究报道了一种基于中空磁性纳米颗粒（HMNP）的生物相容性和热响应性的药物控释系统。该系统的构造简单，只需在HMNP的中空内部填充相变材料（PCM），即熔点为38摄氏度的1-十四醇。该系统实现了疏水性紫杉醇（PTX）和亲水性盐酸阿霉素（DOX）两者的接近“零释放”以及体外精确的“开”或“关”药物递送以有效地诱导细胞凋亡。此外，该系统显示红外热成像和磁共振成像特性。更重要的是，当施加交变磁场时，该系统显示出在体内热化学组合癌症治疗的巨大潜力。
To develop carriers for anti-cancer drug delivery, this study reports a biocompatible and thermal responsive controlled drug delivery system based on hollow magnetic nanoparticles (HMNPs). The system is constructed simply by filling the hollow interiors of HMNPs with a phase-change material (PCM), namely, 1-tetradecanol, which has a melting point of 38 degrees C. The system achieves near "zero release" of both hydrophobic paclitaxel (PTX) and hydrophilic doxorubicin hydrochloride (DOX) and precise "on" or "off" drug delivery in vitro to efficiently induce cell apoptosis. Furthermore, the system displays both infrared thermal imaging and magnetic resonance imaging properties. More importantly, the system demonstrates great potential for thermo-chemo combination cancer therapy in vivo when an alternating magnetic field is applied.