Estrogenic Inhibition of the Hepatic Synthesis of α2u Globulin in the Rat
Estrogenic Inhibition of the Hepatic Synthesis of α2u Globulin in the Rat
复制标题
雌激素对大鼠肝脏α2u球蛋白合成的抑制作用
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
N. M. Biswas
中科院分区：
文献类型：
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作者：
A. Roy;D. M. McMinn;N. M. Biswas
大鼠肝脏合成的雄激素依赖性尿蛋白，称为a2 u球蛋白，受到雌激素的强烈抑制。在成熟雄性大鼠中，雌二醇-17 β（0.5 µg/g体重）治疗可在6-7天内完全抑制α2u合成。停止雌激素治疗后约20天内，α2u的合成不会重新开始。雌激素抑制的雄性大鼠在此滞后期内与其正常同窝出生的大鼠进行异生物结合，未能改变各自配偶体α2u合成的非生物模式。除雌二醇1-17β外，其它雌烷衍生物如雌酮、雌三醇和雌二醇-17 α也能抑制α_2u球蛋白的合成。所有上述抑制α2u合成的雌烷衍生物也被发现抑制成熟雄性大鼠肝胞液雄激素结合蛋白对5α-二氢睾酮的摄取。与已知的翻译抑制剂放线菌酮不同，雌二醇-17 β不抑制灌流大鼠的α2u合成。
The hepatic synthesis of the androgendependent urinary protein in the rat, called a2u globulin, is strongly inhibited by estrogens. In mature male rats, treatment with estradiol-17β (0.5 µg⁄g body weight) completely inhibits α2u synthesis within 6-7 days. Following withdrawal of estrogen treatment α2u synthesis is not reinitiated for approximately 20 days. Parabiotic joining of estrogensuppressed male rats with their normal littermates within this lag period fails to change the preparabiotic pattern of α2u synthesis in the respective partners. Besides estradio 1-17β, other estrane derivatives such as estrone, estriol and estradiol-17α were also found to inhibit the synthesis of α2u globulin. All of the above estrane derivatives which inhibit α2u synthesis are also found to inhibit the uptake of 5α-dihydrotestosterone by the hepatic cytosol androgen binding protein of the mature male rat. Unlike cycloheximide, a known translational inhibitor, estradiol-17β does not inhibit α2u synthesis in the perfused rat...