Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice
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DOI：
10.1182/blood-2003-09-3078
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发表时间：
2004-04-01
期刊：
影响因子：
20.3
通讯作者：
Lentz, SR
中科院分区：
文献类型：
--
作者：
Devlin, AM;Arning, E;Lentz, SR
亚甲基四氢叶酸还原酶（MTHFR）缺乏易患高同型半胱氨酸血症和血管疾病。我们测试了这样的假设：Mthfr 基因的杂合破坏使小鼠对饮食引起的高同型半胱氨酸血症和内皮功能障碍敏感。 Mthfr(+/-) 和 Mthfr(-/+) 小鼠喂食 4 种饮食中的一种：对照、高蛋氨酸 (HM)、低叶酸 (LF) 或高蛋氨酸/低叶酸 (HM/LF)。 LF 和 HM/LF 饮食的血浆总同型半胱氨酸 (tHcy) 高于对照组 (P
Deficiency of methylenetetrahydrofolate reductase (MTHFR) predisposes to hyperhomocysteinemia and vascular disease. We tested the hypothesis that heterozygous disruption of the Mthfr gene sensitizes mice to diet-induced hyperhomocysteinemia and endothelial dysfunction. Mthfr(+/-) and Mthfr(-/+) mice were fed 1 of 4 diets: control, high methionine (HM), low folate (LF), or high methionine/low folate (HM/LF). Plasma total homocysteine (tHcy) was higher with the LF and HM/LF diets than the control (P