A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect.
A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect.
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DOI：
10.4161/onci.22107
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发表时间：
2013-01-01
期刊：
影响因子：
7.2
通讯作者：
Zeiser R
中科院分区：
文献类型：
--
作者：
Thompson LF;Tsukamoto H;Chernogorova P;Zeiser R
异基因干细胞移植治疗恶性血液病的有效性因移植物抗肿瘤(GVT)效应而增强，但受移植物抗宿主病(GvHD)的限制。涉及通过遗传或药物手段抑制CD73的研究表明，CD73产生的腺苷水平可能被操纵以控制GvHD，同时维持GVT效应。
The utility of allogeneic stem cell transplantation for treating hematologic malignancies is enhanced by the graft vs. tumor (GvT) effect, but limited by graft vs. host disease (GvHD). Studies involving the inhibition of CD73 by genetic or pharmacologic means suggest that the levels of CD73-generated adenosine may be manipulated to control GvHD, while maintaining the GvT effect.