Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014-2015
Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014-2015
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DOI：
10.1038/emi.2017.44
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发表时间：
2017-06-21
影响因子：
13.2
通讯作者：
Peiris, Malik
中科院分区：
文献类型：
--
作者：
Hemida, Maged Gomaa;Alnaeem, Abdulmohsen;Peiris, Malik
在2014年9月至2015年5月期间，对两群单峰骆驼的鼻拭子和直肠拭子以及血清进行了纵向采样，并对样本进行了中东呼吸综合征（MERS）冠状病毒RNA和抗体检测。根据三只骆驼鼻拭子中检测到病毒RNA以及其他三只骆驼的抗体滴度显着增加，在一个骆驼群中确认了MERS-CoV感染的证据。这三种病毒在遗传上相同，因此表明该畜群中引入了单一病毒。有证据表明，先前血清学阳性的骆驼再次感染，从而表明，以前的感染并没有提供完全的免疫力，再感染，这一发现是相关的骆驼疫苗接种策略，以防止人畜共患病传播。
Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on the basis of detection of virus RNA in nasal swabs from three camels and significant increases in the antibody titers from three others. The three viruses were genetically identical, thus indicating introduction of a single virus into this herd. There was evidence of reinfection of camels that were previously seropositive, thus suggesting that prior infection does not provide complete immunity from reinfection, a finding that is relevant to camel vaccination strategies as a means to prevent zoonotic transmission.