Nanobiotechnology as a platform for the diagnosis of COVID-19: a review
Nanobiotechnology as a platform for the diagnosis of COVID-19: a review
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DOI：
10.1007/s41204-021-00109-0
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发表时间：
2021-03-24
影响因子：
--
通讯作者：
Badr G
中科院分区：
文献类型：
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作者：
Abdelhamid HN;Badr G
为了应对当前和未来由严重急性呼吸综合征冠状病毒 2 (SARS-CoV 2) 造成的全球健康威胁，迫切需要一种灵敏的 2019 冠状病毒病 (COVID-19) 诊断方法。然而，目前的大多数方法都表现出较高的假阴性率，导致患者误诊并妨碍早期治疗。纳米颗粒显示出良好的性能和巨大的潜力，可以作为短时间内高灵敏度诊断病毒感染的平台。这篇综述强调了纳米颗粒作为诊断 COVID-19 平台的潜力。金纳米粒子、磁性纳米粒子和石墨烯（G）等纳米粒子被应用于检测SARS-CoV 2。它们已用于基于分子的诊断方法和血清学方法。纳米颗粒提高了特异性并缩短了诊断所需的时间。它们可以被应用到小型设备中，以便于在家中或机场和商店等地方进行自我诊断。基于纳米颗粒的方法可用于分析来自患者、表面和空气的病毒污染样本。讨论了优点和挑战，为设计灵敏、快速和低成本的诊断方法提供有用的信息。本次审查旨在提供一项有用的调查，以总结从处理这次疫情中吸取的教训，以便我们为未来的大流行做好准备。
A sensitive method for diagnosing coronavirus disease 2019 (COVID-19) is highly required to fight the current and future global health threats due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2). However, most of the current methods exhibited high false‐negative rates, resulting in patient misdiagnosis and impeding early treatment. Nanoparticles show promising performance and great potential to serve as a platform for diagnosing viral infection in a short time and with high sensitivity. This review highlighted the potential of nanoparticles as platforms for the diagnosis of COVID-19. Nanoparticles such as gold nanoparticles, magnetic nanoparticles, and graphene (G) were applied to detect SARS-CoV 2. They have been used for molecular-based diagnosis methods and serological methods. Nanoparticles improved specificity and shorten the time required for the diagnosis. They may be implemented into small devices that facilitate the self-diagnosis at home or in places such as airports and shops. Nanoparticles-based methods can be used for the analysis of virus-contaminated samples from a patient, surface, and air. The advantages and challenges were discussed to introduce useful information for designing a sensitive, fast, and low-cost diagnostic method. This review aims to present a helpful survey for the lesson learned from handling this outbreak to prepare ourself for future pandemic.