Approaches to N-Methylwelwitindolinone C Isothiocyanate: Facile Synthesis of the Tetracyclic Core
Approaches to N-Methylwelwitindolinone C Isothiocyanate: Facile Synthesis of the Tetracyclic Core
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DOI：
10.1021/ol1006373
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发表时间：
2010-06-04
期刊：
影响因子：
5.2
通讯作者：
Martin, Stephen F.
中科院分区：
文献类型：
--
作者：
Heidebrecht, Richard W., Jr.;Gulledge, Brian;Martin, Stephen F.
报道了一种功能化的四环核N-甲基维吲哚啉酮C异硫氰酸酯的合成。该方法的特点是一个收敛的吲哚亚胺离子和高度官能化的乙烯基甲硅烷基烯酮缩醛之间的耦合，然后通过烯醇化芳基化进行分子内钯催化的环化。
The synthesis of a functionalized, tetracyclic core of N-methylwelwitindolinone C isothiocyanate is reported. The approach features a convergent coupling between an indole iminium ion and a highly functionalized vinylogous silyl ketene acetal followed by an intramolecular palladium-catalyzed cyclization that proceeds via an enolate arylation.