Sexual Dimorphism in the Human Corpus Callosum: An MRI Study Using the OASIS Brain Database
Sexual Dimorphism in the Human Corpus Callosum: An MRI Study Using the OASIS Brain Database
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DOI：
10.1093/cercor/bhs253
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发表时间：
2013-10-01
期刊：
影响因子：
3.7
通讯作者：
Sidtis, John J.
中科院分区：
文献类型：
--
作者：
Ardekani, Babak A.;Figarsky, Khadija;Sidtis, John J.
许多研究报告说，“相对于大脑的大小，”女性的中间矢状面的胼胝体横截面积(CCA)平均比男性大。然而，其他人认为，这些可能是CCA与脑大小比率造成的虚假差异，因为男性的脑大小往往更大。为了帮助解决这一争议，我们测量了OASIS(开放式获取系列成像研究)横断面数据集中所有316名正常受试者(18-94岁)的磁共振成像(MRI)扫描的CCA，并使用多元回归分析对大脑大小和年龄的混杂影响进行统计控制，以检验平均CCA在性别之间没有差异的零假设。另一项分析是对74名与大脑大小匹配的年轻人(37名男性和37名女性；18-29岁)进行的另外一组分析。我们的零假设在两个分析中都被拒绝了。在整个样本(n=316)中，控制了大脑大小和年龄，女性的平均CCA显著更大(P<；0.03)。这种偏向女性的差异在年轻人队列中更为明显(P<；0.0005)。这些结果提供了强有力的补充证据，表明在校正了大脑的混杂效应后，女性的CCA更大
A number of studies have reported that, "relative to brain size," the midsagittal corpus callosum cross-sectional area (CCA) in females is on average larger than in males. However, others suggest that these may be spurious differences created in the CCA-to-brain-size ratio because brain size tends to be larger in males. To help resolve this controversy, we measured the CCA on all 316 magnetic resonance imaging (MRI) scans of normal subjects (18-94 years) in the OASIS (Open Access Series of Imaging Studies) cross-sectional dataset, and used multiple regression analysis to statistically control for the confounding effects of brain size and age to test the null hypothesis that the average CCA is not different between genders. An additional analysis was performed on a subset of 74 young adults (37 males and 37 females; 18-29 years) matched closely to brain size. Our null hypothesis was rejected in both analyses. In the entire sample (n = 316), controlling for brain size and age, the average CCA was significantly (P < 0.03) larger in females. The difference favoring females was more pronounced in the young adults cohort (P < 0.0005). These results provide strong additional evidence that the CCA is larger in females after correcting for the confounding effect of brain