Peptide epitopes from noncytosolic Listeria monocytogenes can be presented by major histocompatibility complex class I molecules.
Peptide epitopes from noncytosolic Listeria monocytogenes can be presented by major histocompatibility complex class I molecules.
复制标题
来自非胞质单核细胞增生李斯特氏菌的肽表位可由主要组织相容性复合物 I 类分子呈递。
DOI：
10.1128/iai.64.5.1870-1872.1996
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发表时间：
1996
影响因子：
3.1
通讯作者：
Potter,TA
中科院分区：
文献类型：
--
作者：
Zwickey,HL;Potter,TA
单核细胞增多性李斯特菌是一种细胞内的病原体，它能逃避吞噬体而驻留在宿主细胞的胞质溶胶中。利用无害李斯特菌和一株变异的李斯特菌。单核细胞增多症（溶血素O阴性），不进入宿主细胞的胞质溶胶，我们证明了p60的表位的I类呈递，p60是由L.单核细胞增多症，I类限制性CD8+细胞毒性T淋巴细胞克隆。
Listeria monocytogenes is an intracellular pathogen which escapes the phagosome and resides in the cytosol of the host cell. Using Listeria innocua and a mutant strain of L. monocytogenes (listeriolysin O negative), which do not enter the cytosol of the host cell, we demonstrate class I presentation of an epitope of p60, a protein secreted by L. monocytogenes, to a class I-restricted CD8+ cytotoxic T lymphocyte clone.