Control of synchronization of brain dynamics leads to control of epileptic seizures in rodents.
Control of synchronization of brain dynamics leads to control of epileptic seizures in rodents.
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DOI：
10.1142/s0129065709001951
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发表时间：
2009-06
影响因子：
8
通讯作者：
Iasemidis L
中科院分区：
文献类型：
--
作者：
Good LB;Sabesan S;Marsh ST;Tsakalis K;Treiman D;Iasemidis L
我们已经设计并实现了一个自动化的，即时刺激，癫痫发作控制方法，使用癫痫发作预测方法，从非线性动力学耦合脑深部刺激在丘脑中央核的癫痫大鼠。还进行了与具有相同刺激参数的周期性刺激的比较。比较了两种方案在控制癫痫发作方面的有效性，以及它们对脑动力学同步的影响。自动即时（JIT）刺激显示6只大鼠中有5只的癫痫发作频率和持续时间减少，其中33%的大鼠癫痫发作频率显著减少（>50%）。这构成了对相同动物的定期控制方案的有效性的显著改善。实际上，周期性刺激显示50%的大鼠癫痫发作频率增加，3只大鼠癫痫发作频率减少，1只大鼠显著减少。重要的是，成功的癫痫控制与脑动力学的去兴奋化高度相关。这项研究提供了初步的证据，使用闭环反馈控制系统在癫痫发作结合癫痫发作预测和脑深部电刺激的方法。
We have designed and implemented an automated, just-in-time stimulation, seizure control method using a seizure prediction method from nonlinear dynamics coupled with deep brain stimulation in the centromedial thalamic nuclei in epileptic rats. A comparison to periodic stimulation, with identical stimulation parameters, was also performed. The two schemes were compared in terms of their efficacy in control of seizures, as well as their effect on synchronization of brain dynamics. The automated just-in-time (JIT) stimulation showed reduction of seizure frequency and duration in 5 of the 6 rats, with significant reduction of seizure frequency (>50%) in 33% of the rats. This constituted a significant improvement over the efficacy of the periodic control scheme in the same animals. Actually, periodic stimulation showed an increase of seizure frequency in 50% of the rats, reduction of seizure frequency in 3 rats and significant reduction in 1 rat. Importantly, successful seizure control was highly correlated with desynchronization of brain dynamics. This study provides initial evidence for the use of closed-loop feedback control systems in epileptic seizures combining methods from seizure prediction and deep brain stimulation.