Fundamental Studies of Hyperthermia Using Magnetic Particles as Thermo-seeds: 1: Development of Magnetic Particles Suitable for Hyperthermia
Fundamental Studies of Hyperthermia Using Magnetic Particles as Thermo-seeds: 1: Development of Magnetic Particles Suitable for Hyperthermia
复制标题
使用磁性粒子作为热种子的热疗基础研究：1：适合热疗的磁性粒子的开发
DOI：
10.3379/jmsjmag.30.555
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
K. Tohji
中科院分区：
文献类型：
--
作者：
T. Atsumi;B. Jeyadevan;Y. Sato;K. Tohji
讨论了适合热疗的磁性材料，考虑了它们的磁性、治疗条件和仪器的实际限制。实验结果表明，具有极低各向异性常数的铁磁粒子或具有中等各向异性常数的超顺磁粒子都是合适的。考虑到颗粒的磁性和生物相容性，直径为11-13 nm的超顺磁性Fe3O4被认为是最合适的。采用共沉淀法和热分解法成功合成了不同粒径的Fe3O4颗粒，并对其升温速率进行了实验验证。产生的热量取决于颗粒直径和固体浓度。平均粒径为14 nm，固相浓度为4 wt.%的Fe3O4悬浮液在3.2 kA/m和600 kHz的交流磁场强度和频率下作用10分钟，温度从室温上升到100℃。
Magnetic materials suitable for hyperthermia are discussed taking their magnetic properties, practical limitations of treatment conditions and instrumentation into consideration. The experimental results suggest that either ferromagnetic particle with very low anisotropy constant or superparamagnetic particles with a moderate anisotropy constant are suitable. Considering the magnetic- and biocompatibility of the particles, superparamagnetic Fe3O4 with a diameter of 11-13 nm is considered most appropriate. Fe3O4 particles of various diameters were successfully synthesized using coprecipitation and thermal decomposition and their heating rates were experimentally verified. The heat generated depends on the particle diameter and solid concentration. The temperature of 3 ml Fe3O4 suspension with an average particle diameter of 14 nm and solid concentration of 4 wt.% rose from room temperature to 100 °C, when it was exposed to an ac magnetic field strength and frequency of 3.2 kA/m and 600 kHz respectively for 10 minutes.